What causes psoriatic arthritis?

Psoriatic arthritis is caused by an overactive immune system that mistakenly attacks healthy joint tissues and skin cells. The exact trigger is unknown, but genetic factors play a significant role, particularly the presence of the HLA-B27 antigen, which increases susceptibility to the condition. Environmental factors like infections, physical trauma, and stress can also trigger the onset of symptoms in people who are genetically predisposed.

What is the best test for psoriatic arthritis?

The HLA-B27 Antigen test is the most important test for psoriatic arthritis because it identifies the genetic marker associated with increased risk and more severe disease forms. This test helps predict disease progression and guides treatment decisions. Additional supporting tests include the Interleukin 17 Serum test, which measures inflammatory activity, and the Anti-CCP3 IgG test, which helps differentiate psoriatic arthritis from rheumatoid arthritis in cases where symptoms overlap. The HLA B Low Resolution test provides comprehensive genetic typing for thorough risk assessment.

When should I get tested for psoriatic arthritis?

You should get tested if you have psoriasis and start experiencing joint pain, stiffness, or swelling, especially in the morning or after periods of rest. Testing is also recommended if you notice swollen fingers or toes that look like sausages, heel pain, lower back pain, or nail changes like pitting or separation from the nail bed. Early testing is crucial because early diagnosis and treatment can prevent permanent joint damage and improve long-term outcomes.

What are the symptoms of psoriatic arthritis?

Symptoms of psoriatic arthritis include joint pain, stiffness, and swelling that typically affects the fingers, toes, wrists, knees, and ankles. You might notice morning stiffness that lasts more than 30 minutes, swollen fingers or toes that resemble sausages, lower back or neck pain, and fatigue. Skin symptoms include red, scaly psoriasis patches, and nail changes like pitting, crumbling, or separation from the nail bed. Some people also experience eye inflammation causing redness and pain.

Who is at risk for psoriatic arthritis?

People with psoriasis are at the highest risk, with about 30% developing psoriatic arthritis, usually within 10 years of their psoriasis diagnosis. Those who carry the HLA-B27 genetic marker face increased risk and tend to develop more severe disease. Family history significantly increases risk, as the condition tends to run in families. The condition typically develops between ages 30 and 50, and factors like obesity, smoking, and physical trauma to joints can trigger onset in susceptible individuals.

What happens if psoriatic arthritis is left untreated?

Untreated psoriatic arthritis leads to progressive and permanent joint damage, including joint deformities that affect mobility and quality of life. The chronic inflammation can cause bone erosion and fusion of small bones in the hands and feet, making everyday tasks difficult. Beyond joints, untreated disease increases risk of cardiovascular disease, metabolic syndrome, and depression. Early and aggressive treatment is essential to prevent irreversible damage and maintain joint function over time.

Can psoriatic arthritis be diagnosed with a blood test?

Blood tests cannot definitively diagnose psoriatic arthritis on their own, but they provide crucial information for assessment and diagnosis. The HLA-B27 Antigen test identifies genetic risk factors, while inflammatory markers like Interleukin 17 measure disease activity. Blood tests also help rule out rheumatoid arthritis by checking for CCP antibodies, which are usually absent in psoriatic arthritis. Diagnosis requires combining blood test results with physical examination, medical history, imaging studies, and the presence of psoriasis.

How is psoriatic arthritis treated?

Treatment for psoriatic arthritis focuses on controlling inflammation, relieving pain, and preventing joint damage. Nonsteroidal anti-inflammatory drugs reduce pain and swelling, while disease-modifying antirheumatic drugs slow disease progression. Biologic medications that target specific immune system proteins, particularly those blocking Interleukin 17, are highly effective for moderate to severe disease. Physical therapy helps maintain joint flexibility and strength, and lifestyle modifications including regular exercise, maintaining a healthy weight, and stress management support overall treatment effectiveness.

How can I prevent psoriatic arthritis?

While you cannot prevent psoriatic arthritis if you have genetic predisposition, you can reduce your risk of triggering the condition or worsening symptoms. Maintaining a healthy weight reduces stress on joints and decreases inflammation throughout the body. Avoiding smoking and limiting alcohol consumption helps protect joint health. Protecting your joints from injury and managing stress through relaxation techniques can prevent symptom flares. If you have psoriasis, working closely with your healthcare provider for early detection and prompt treatment is the best preventive strategy.

What natural remedies help with psoriatic arthritis?

Natural approaches can complement medical treatment for psoriatic arthritis symptoms. Omega-3 fatty acids from fish oil have anti-inflammatory properties that may reduce joint pain and stiffness. Turmeric and its active compound curcumin show promise in reducing inflammation when taken as supplements. Regular gentle exercise like swimming, yoga, and tai chi helps maintain joint flexibility without adding stress. Applying hot and cold therapy alternately can relieve pain and reduce swelling, while maintaining an anti-inflammatory diet rich in fruits, vegetables, and whole grains supports overall health.

Getting your blood test with us is easy, private & backed by the power of science.Long story short: In the test options, use the filters or search box to narrow your choices and find the test you want. If you need a hand navigating through options, text our super friendly support team at 754-799-7833, and we'll provide tailored suggestions to help you find the ideal test. Once your order is placed, we’ll create your doctor’s lab order remotely, without any need for you to make a trip to a doctor in person or to talk to the doctor. Expect to receive your doctor’s lab order right in your inbox. It will also be in your patient portal if you need to find it later. We’ll also include instructions regarding fasting and other requirements for your test. Your patient portal will be auto-created hassle-free during checkout. If this is your first time ordering, you'll be prompted to create a password for instant login access to your patient portal. It's a quick way to conveniently access your orders and results whenever you want. When you’re ready, visit one of our 4,000 locations. Just bring your ID – no printing or faxing of your lab order is needed, as your order and details will already be in the lab system. Note that most lab locations don’t accept walk-ins, so it’s best to book an appointment in advance. Don’t worry – we’ll provide detailed instructions along the way. You’ll get your results via email & SMS and dive into understanding your body better. Yup, that easy! If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com and we'll gladly help you.

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Psoriatic Arthritis Blood Test

What is Psoriatic Arthritis?

Psoriatic arthritis is an inflammatory joint condition affecting people with psoriasis, causing joint pain, stiffness, and swelling. It occurs when the immune system attacks healthy joints and skin cells, triggering chronic inflammation. The HLA-B27 Antigen test is the most important test for assessing genetic risk and predicting disease severity.

Written by Private MD Labs Medical Team

Last updated: December 30, 2025

Getting your blood test with us is easy, private & backed by the power of science.

Long story short:

In the test options, use the filters or search box to narrow your choices and find the test you want.
If you need a hand navigating through options, text our super friendly support team at 754-799-7833, and we'll provide tailored suggestions to help you find the ideal test.
Once your order is placed, we’ll create your doctor’s lab order remotely, without any need for you to make a trip to a doctor in person or to talk to the doctor. Expect to receive your doctor’s lab order right in your inbox. It will also be in your patient portal if you need to find it later. We’ll also include instructions regarding fasting and other requirements for your test. Your patient portal will be auto-created hassle-free during checkout.
If this is your first time ordering, you'll be prompted to create a password for instant login access to your patient portal. It's a quick way to conveniently access your orders and results whenever you want.
When you’re ready, visit one of our 4,000 locations. Just bring your ID – no printing or faxing of your lab order is needed, as your order and details will already be in the lab system.
Note that most lab locations don’t accept walk-ins, so it’s best to book an appointment in advance. Don’t worry – we’ll provide detailed instructions along the way.
You’ll get your results via email & SMS and dive into understanding your body better. Yup, that easy!

754-799-7833

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