Understanding Lab Tests for Primary Aldosteronism (Conn's Syndrome)
Written by Private MD Labs Medical Writing Team • Last Updated: September 8, 2025
Primary aldosteronism, also known as Conn's syndrome, is a hormonal disorder where the adrenal glands produce excessive amounts of aldosterone. This hormone imbalance leads to high blood pressure, low potassium levels, and other serious health complications. Specialized blood tests are essential for diagnosing this condition.
Recommended Test
Aldosterone/Plasma Renin Activity Ratio, LC/MS/MS
This test directly measures the balance between aldosterone hormone and plasma renin activity in your blood. In Primary Aldosteronism, the adrenal glands produce excess aldosterone while renin levels remain suppressed, resulting in an elevated ratio. This test is the primary screening tool for diagnosing Conn's syndrome and helps healthcare providers confirm whether your symptoms are caused by hormonal overproduction.
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How Primary Aldosteronism is Diagnosed
Primary aldosteronism is often suspected in patients with resistant high blood pressure or unexplained low potassium levels. A specific blood test measuring the ratio between aldosterone and renin activity provides crucial diagnostic information. An elevated ratio typically indicates excessive aldosterone production, confirming the diagnosis.
Understanding Your Results
An elevated aldosterone-to-renin ratio suggests possible primary aldosteronism. However, results must be interpreted by a healthcare provider who will consider your symptoms, medical history, and may recommend additional confirmatory tests to establish a definitive diagnosis and determine the most appropriate treatment approach.
Important Considerations
The information here is for educational purposes only and is not a substitute for professional medical advice. Always consult with a healthcare provider for diagnosis and treatment.
