Understanding Lab Tests for Primary Aldosteronism
Written by Private MD Labs Medical Writing Team • Last Updated: September 8, 2025
Primary aldosteronism, also known as Conn's syndrome, is a hormonal disorder characterized by the overproduction of aldosterone from one or both adrenal glands. This excess aldosterone can lead to high blood pressure and low potassium levels. Blood testing is the primary method for diagnosing this condition.
Recommended Test
Aldosterone/Plasma Renin Activity Ratio, LC/MS/MS
This test is the gold standard for diagnosing primary aldosteronism. It measures the ratio between aldosterone and plasma renin activity (PRA). In primary aldosteronism, this ratio is typically elevated due to excess aldosterone production that occurs independently of renin stimulation. The condition is characterized by overproduction of aldosterone from the adrenal glands, which can lead to high blood pressure and low potassium levels.
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How Primary Aldosteronism is Diagnosed
Primary aldosteronism is diagnosed through specialized blood tests that measure hormone levels. The condition occurs when the adrenal glands produce too much aldosterone independent of the normal regulatory mechanisms, making blood testing essential for accurate diagnosis.
Understanding the Test Results
An elevated aldosterone to plasma renin activity ratio suggests that the body is producing too much aldosterone relative to renin levels. This imbalance is the hallmark of primary aldosteronism and helps healthcare providers distinguish it from other causes of high blood pressure.
Important Considerations
The information here is for educational purposes only and is not a substitute for professional medical advice. Always consult with a healthcare provider for diagnosis and treatment.
