Understanding Lab Tests for Post-Prostatectomy PSA Persistence
Written by Private MD Labs Medical Writing Team • Last Updated: September 8, 2025
Post-prostatectomy PSA persistence refers to the continued presence of detectable prostate-specific antigen (PSA) levels in the blood following surgical removal of the prostate gland. Since the prostate is the primary source of PSA production, levels should typically become undetectable after a successful prostatectomy.
Recommended Test
Prostate-Specific Antigen (PSA), Ultrasensitive, Post Prostatectomy (MALES ONLY)
This specialized ultrasensitive PSA test is specifically designed for men who have undergone prostatectomy. It can detect extremely low levels of PSA that would be missed by standard PSA tests. Since PSA should fall to undetectable levels following complete prostate removal, any persistent detectable PSA levels could indicate the presence of residual prostate tissue or cancer recurrence, making this test essential for post-surgical monitoring.
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Why Specialized PSA Testing is Critical After Prostatectomy
Standard PSA tests may not be sensitive enough to detect the very low levels that could indicate problems after prostate removal. An ultrasensitive PSA test is specifically designed to measure extremely low concentrations of PSA that might remain in the bloodstream, providing crucial information about treatment success and potential complications.
Understanding PSA Persistence vs. Recurrence
PSA persistence typically means that PSA levels never dropped to undetectable levels after surgery, which may suggest that some prostate tissue or cancer cells remained. This is different from PSA recurrence, where levels initially drop to undetectable but then rise again over time. Both scenarios require careful monitoring and medical evaluation.
When to Consider Testing
Post-prostatectomy PSA monitoring is typically recommended at regular intervals following surgery, usually starting 6-8 weeks after the procedure and continuing according to your healthcare provider's schedule. The timing and frequency of testing may vary based on individual risk factors and initial cancer characteristics.
Important Considerations
Persistent or rising PSA levels after prostatectomy require immediate medical evaluation and may indicate the need for additional treatment. The information provided here is for educational purposes only and is not a substitute for professional medical advice. Always consult with your healthcare provider or oncologist for proper interpretation of PSA results and treatment planning.
