Understanding Lab Tests for Peripheral Arterial Disease
Written by Private MD Labs Medical Writing Team • Last Updated: September 8, 2025
Peripheral Arterial Disease (PAD) is a circulatory condition where narrowed arteries reduce blood flow to the limbs, typically affecting the legs. While PAD is primarily diagnosed through physical examination and imaging studies like ankle-brachial index (ABI), blood tests play a crucial supporting role by identifying cardiovascular risk factors and inflammatory markers associated with arterial plaque formation.
Recommended Test
Lp-PLA2 Activity(6)
This test measures the activity of lipoprotein-associated phospholipase A2, an enzyme that plays a significant role in the formation of atherosclerotic plaques. Increased Lp-PLA2 levels may indicate active inflammatory processes within arterial walls and the presence of unstable plaques, making it a valuable biomarker for assessing peripheral arterial disease risk and arterial inflammation.
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The Role of Blood Testing in PAD Assessment
Although there isn't a single blood test that directly diagnoses PAD, laboratory testing is fundamental for evaluating cardiovascular risk, detecting inflammatory processes that contribute to atherosclerosis, and monitoring the progression of arterial disease. These tests help healthcare providers understand the underlying mechanisms driving plaque buildup in peripheral arteries.
Understanding Your Results
Elevated Lp-PLA2 activity levels suggest increased cardiovascular risk and may indicate ongoing arterial inflammation that contributes to PAD development and progression. This information, combined with clinical evaluation, helps guide treatment strategies and cardiovascular risk management.
Important Considerations
The information here is for educational purposes only and is not a substitute for professional medical advice. Always consult with a healthcare provider for diagnosis and treatment of peripheral arterial disease.
