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Peptic ulcers are open sores that develop in the lining of the stomach or upper small intestine. They are caused by Helicobacter pylori bacteria infection, long-term use of nonsteroidal anti-inflammatory drugs (NSAIDs), or excessive stomach acid production stimulated by elevated histamine levels. The Histamine Plasma test is the most important test for assessing acid-related ulcer risk because it measures the chemical that directly triggers gastric acid secretion.
Peptic ulcers are caused by Helicobacter pylori bacteria infection, regular use of pain relievers like aspirin and ibuprofen (NSAIDs), and excessive stomach acid production. H. pylori bacteria weaken the protective mucus coating of your stomach and small intestine, allowing acid to damage the sensitive lining underneath. NSAIDs interfere with your stomach's ability to protect itself from acid, while elevated histamine levels trigger excess acid secretion that can erode the digestive tract lining over time.
The Histamine Plasma test is the most important blood test for peptic ulcers because it measures histamine levels that directly control how much stomach acid your body produces. Elevated histamine triggers excessive gastric acid secretion, which can damage your stomach lining and worsen existing ulcers. While peptic ulcers are typically diagnosed through endoscopy, the Histamine Plasma test helps identify whether your body's chemical signals are contributing to acid overproduction, allowing your doctor to address one of the root causes of ulcer formation and recurrence.
You should get tested if you experience persistent burning stomach pain between meals or at night, especially pain that temporarily improves after eating or taking antacids. Get tested if you notice unexplained weight loss, dark or bloody stools, persistent nausea or vomiting, or if you regularly take NSAIDs like ibuprofen or aspirin. Early testing is important because untreated ulcers can lead to serious complications like bleeding or perforation of the stomach wall.
What this means
Your plasma histamine level is elevated above the optimal range, which may indicate an active allergic response or excessive histamine release in your body. This elevation could explain symptoms like hives, flushing, itching, or digestive issues you may be experiencing.
Recommended actions
Follow a low-histamine diet by avoiding aged cheeses, fermented foods, alcohol, and processed meats
Keep a symptom diary to identify potential triggers for histamine release
Manage stress through meditation or yoga, as stress can trigger histamine release
Consider retesting in 4-8 weeks after dietary and lifestyle modifications
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