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Peptic ulcer disease is a condition where painful sores develop in the lining of the stomach or duodenum. It is caused by infection with Helicobacter pylori bacteria or long-term use of NSAIDs that weaken the protective mucous coating. The H. Pylori Antigen Stool test is the most important test for diagnosis because it directly detects active bacterial infection.
Peptic ulcer disease is caused primarily by infection with Helicobacter pylori bacteria, which weakens the protective mucous layer of the stomach and duodenum. Long-term use of nonsteroidal anti-inflammatory drugs (NSAIDs) like aspirin and ibuprofen is the second most common cause, as these medications reduce the stomach's ability to protect itself from acid. Other contributing factors include excessive alcohol consumption, smoking, and severe physical stress from illness or surgery.
The H. Pylori Antigen Stool test is the most important test for peptic ulcer disease because it directly detects active Helicobacter pylori infection in your digestive system. This test identifies the bacterial antigens in a stool sample, confirming whether H. pylori is present and causing your ulcers. Unlike antibody blood tests that can remain positive even after treatment, the stool antigen test shows current infection status, making it ideal for both initial diagnosis and confirming successful treatment. Identifying H. pylori allows your healthcare provider to prescribe targeted antibiotic therapy that can eliminate the bacteria and cure the underlying cause of most peptic ulcers.
You should get tested if you experience persistent burning stomach pain, especially between meals or at night, or if you notice dark or bloody stools. Testing is also important if you have frequent heartburn, nausea, bloating, or unexplained weight loss, as these symptoms may indicate an ulcer. Get tested immediately if you have severe abdominal pain, vomiting blood, or difficulty swallowing, as these could signal serious complications requiring urgent medical attention.
What this means
Your test came back negative, meaning no H. Pylori bacteria was detected in your stool sample. This is a healthy result that rules out H. Pylori as the cause of your digestive symptoms. If you continue experiencing stomach issues, other causes such as diet, stress, or other gastrointestinal conditions may need to be explored.
Recommended actions
Maintain a balanced diet with plenty of fiber and avoid trigger foods like spicy or acidic items
Manage stress through relaxation techniques as it can affect digestion
Keep a food diary to identify any patterns with digestive discomfort
If symptoms persist, consult with a gastroenterologist to explore other possible causes
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