Understanding Lab Tests for Paget's Disease of Bone
Written by Private MD Labs Medical Writing Team • Last Updated: September 8, 2025
Paget's disease of bone is a chronic disorder that affects normal bone remodeling, causing bones to become enlarged, weakened, and deformed. While the diagnosis is typically made through imaging studies and physical examination, blood tests play a crucial role in monitoring disease activity and treatment effectiveness.
Recommended Test
C-Telopeptide, Serum
This test measures C-telopeptide levels, which are released when bone tissue is broken down. In Paget's disease, the chronic disorder leads to abnormal bone destruction and regrowth cycles, resulting in elevated C-telopeptide levels. Monitoring these levels helps assess disease activity and evaluate how well treatments are working to control bone turnover.
2907 reviews
Why Blood Testing is Important in Paget's Disease
Although there isn't a single blood test to diagnose Paget's disease itself, laboratory testing is fundamental for assessing bone metabolism activity. The abnormal bone destruction and regrowth characteristic of this condition releases specific markers into the bloodstream that can be measured and monitored over time.
Understanding Your Results
Elevated C-telopeptide levels may indicate increased bone breakdown activity, which is common in active Paget's disease. Your healthcare provider will interpret these results alongside your symptoms, physical examination findings, and imaging studies to develop an appropriate treatment plan.
Important Considerations
The information here is for educational purposes only and is not a substitute for professional medical advice. Always consult with a healthcare provider for diagnosis and treatment.
