Ovarian tumors are abnormal growths that develop in or on the ovaries and can be benign or malignant. Many ovarian tumors produce excess estrogen and estradiol hormones that enter the bloodstream and stimulate further tumor growth. The Estrogens (Total), Serum test is the most important test for detecting hormonal complications from ovarian tumors.
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Ovarian tumors are caused by abnormal cell growth in or on the ovaries, which can develop from various cell types including epithelial cells, germ cells, or stromal cells. The exact cause varies depending on the tumor type, but many hormone-producing tumors develop from granulosa cells or theca cells that naturally produce estrogen and estradiol. Risk factors include genetic mutations (especially BRCA1 and BRCA2), family history of ovarian or breast cancer, age, endometriosis, and hormone replacement therapy.
The Estrogens (Total), Serum test is the most important blood test for ovarian tumors because it detects elevated estrogen levels that indicate hormone-producing tumor activity. This test measures all forms of estrogen in your bloodstream, which can be significantly elevated when tumors actively secrete hormones. For comprehensive monitoring, the Estradiol, Ultrasensitive, LC/MS/MS test provides highly sensitive detection of estradiol, the most potent estrogen form, while the Estriol, LC/MS/MS, Serum test identifies elevated estriol levels that can signal estrogen-producing tumors in non-pregnant women. While imaging studies like ultrasound and CT scans diagnose the tumor itself, these blood tests are essential for assessing hormonal complications and monitoring treatment response.
You should get tested if you experience irregular or abnormal menstrual periods, persistent pelvic or abdominal pain, bloating that does not go away, feeling full quickly when eating, or unexplained breast tenderness. Women with a family history of ovarian or breast cancer, those with genetic mutations like BRCA1 or BRCA2, or anyone experiencing symptoms of excess estrogen such as mood changes or unexpected vaginal bleeding should also consider testing. Testing is particularly important if symptoms persist for more than two weeks or interfere with daily activities.
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What this means
Your total estrogen levels are slightly below the optimal range. While not necessarily alarming, low estrogen can contribute to mood changes, irregular periods, fatigue, and decreased bone density over time. Understanding this helps you take proactive steps to support your hormonal health.
Recommended actions
Include phytoestrogen-rich foods like flax seeds, soy products, and legumes in your diet
Engage in regular moderate exercise, but avoid overtraining which can lower estrogen
Prioritize 7-8 hours of quality sleep and manage stress through relaxation techniques
Consider retesting in 3-6 months to monitor trends and evaluate interventions
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