Written by Private MD Labs Medical Writing Team • Last Updated: September 8, 2025
Ovarian failure, also known as primary ovarian insufficiency (POI), occurs when the ovaries stop functioning normally before age 40. This condition affects hormone production and can lead to irregular periods, infertility, and early menopause symptoms. Blood tests measuring hormone levels are essential for diagnosing this condition.
This test measures estradiol levels in the blood, which is one of the primary hormones produced by the ovaries. In ovarian failure, estradiol levels are typically low because the ovaries are not functioning properly. Low estradiol can explain symptoms such as missed periods, infertility, and early menopause-like symptoms, making this test crucial for diagnosis.
Since ovarian failure primarily involves hormonal dysfunction, blood tests that measure specific hormone levels are the primary diagnostic tools. These tests can reveal decreased hormone production from the ovaries, confirming the diagnosis and helping healthcare providers determine the best treatment approach.
Low estradiol levels, particularly when combined with symptoms like irregular menstrual cycles or fertility issues, may indicate ovarian failure. Your healthcare provider will interpret these results alongside your medical history and symptoms to make an accurate diagnosis and recommend appropriate treatment options.
The information here is for educational purposes only and is not a substitute for professional medical advice. Always consult with a healthcare provider for diagnosis and treatment of ovarian failure or any reproductive health concerns.