Orthostatic hypotension is a sudden drop in blood pressure when standing up from a sitting or lying position. It is caused by the body's inability to produce adequate norepinephrine and other catecholamines in response to position changes. The Catecholamines, Fractionated, Plasma test is the most important test for identifying autonomic nervous system dysfunction causing orthostatic hypotension.
90-day money-back guarantee
Lab order in minutes
Save a trip to the doctor
Low prices since 2005
Labs within 2 miles
Orthostatic hypotension is caused by the autonomic nervous system's failure to properly regulate blood pressure when changing positions. When you stand up, gravity causes blood to pool in your legs, and normally your nervous system releases norepinephrine and other catecholamines to constrict blood vessels and maintain blood flow to your brain. When this system malfunctions due to nerve damage, medication side effects, dehydration, or underlying conditions like diabetes or Parkinson's disease, blood pressure drops too quickly, causing dizziness or fainting.
The Catecholamines, Fractionated, Plasma test is the most important blood test for orthostatic hypotension because it measures norepinephrine, epinephrine, and dopamine levels that are essential for blood pressure regulation. This test reveals whether your autonomic nervous system is producing adequate catecholamines to respond when you stand up. Low norepinephrine levels specifically indicate autonomic dysfunction, which is a primary cause of orthostatic hypotension. Your healthcare provider will also diagnose the condition by measuring your blood pressure while lying down and after standing, but the catecholamine test identifies the underlying biochemical cause.
You should get tested if you regularly feel dizzy or lightheaded when standing up from sitting or lying down, especially if you have actually fainted or nearly fainted. Testing is particularly important if you experience blurred vision, weakness, confusion, or nausea when changing positions, or if you have conditions like diabetes or Parkinson's disease that affect nerve function. You should also consider testing if you take medications for high blood pressure or heart conditions and develop these symptoms, as they may indicate your nervous system's ability to regulate blood pressure is compromised.
Save a trip to the doctor, go directly to the lab
Instant orders, results often overnight*
Results explained in simple language
Reviewed by US licensed doctors
Fast & confidential, we never sell or share your data
No insurance needed, transparent pricing
What this means
Your norepinephrine level is elevated above the optimal range, which may indicate excess stress hormone production. While this can sometimes occur during periods of high stress or anxiety, persistently elevated levels may suggest a hormone-producing tumor or other medical condition that requires further evaluation.
Recommended actions
Discuss these results with your doctor, especially if you have symptoms like rapid heartbeat or high blood pressure
Your doctor may recommend imaging tests to check for hormone-producing tumors
Avoid stimulants like caffeine and ensure adequate rest before any repeat testing
Follow up with additional testing as recommended by your healthcare provider
Not overhyped or overpriced. Just comprehensive blood testing made simple and for everyone.
3303 reviews
Sample results
Your 24/7 Personal Lab Guide
Quick questions:
