Sample results
Obesity is a complex metabolic disorder characterized by excessive body fat accumulation that impairs health. It is caused by insulin resistance, leptin resistance, hormonal imbalances including low adiponectin and reduced sex hormone binding globulin (SHBG), and disrupted fat metabolism involving elevated TMAO levels. The Proinsulin test is the most important test for obesity diagnosis because it directly measures insulin resistance, the primary metabolic dysfunction driving weight gain.
Obesity is caused by insulin resistance, leptin resistance, hormonal imbalances, and disrupted fat metabolism. Insulin resistance occurs when your cells stop responding properly to insulin, causing your body to store more fat and making weight loss extremely difficult. Leptin resistance means your brain no longer receives signals that you are full, leading to constant hunger and overeating. Additional factors include low adiponectin levels (a fat-regulating hormone), reduced sex hormone binding globulin (SHBG) causing hormonal imbalances, and elevated TMAO levels that disrupt how your body processes and stores fat.
The Proinsulin test is the most important test for obesity because it directly measures insulin resistance, the primary metabolic dysfunction driving weight gain and making weight loss difficult. Elevated proinsulin levels indicate your body is struggling to process sugar properly and is storing excess calories as fat. Additional essential tests include the Leptin Serum test to assess leptin resistance and appetite regulation, the Adiponectin test to evaluate fat tissue metabolism, the Sex Hormone Binding Globulin (SHBG) test to identify hormonal imbalances contributing to weight gain, and the TMAO test to detect disrupted fat metabolism pathways.
You should get tested if you have difficulty losing weight despite diet and exercise, experience constant hunger or cravings even after eating, notice weight gain concentrated around your midsection, have a family history of diabetes or metabolic syndrome, or struggle with fatigue and low energy levels. Testing is especially important if you have other risk factors like high blood pressure, elevated cholesterol, or prediabetes. Early detection of insulin resistance and hormonal imbalances allows you to address the root metabolic causes of weight gain before they lead to serious complications like type 2 diabetes or heart disease.
What this means
Your proinsulin level is elevated above the optimal range, which may indicate your pancreas is producing more proinsulin than usual or not converting it efficiently to insulin. This can be associated with insulin resistance, prediabetes, or in rare cases, an insulinoma. Elevated proinsulin may contribute to blood sugar fluctuations and symptoms like shakiness or fatigue between meals.
Recommended actions
Focus on balanced meals with protein, healthy fats, and complex carbs to stabilize blood sugar
Eat smaller, more frequent meals throughout the day to prevent blood sugar drops
Incorporate regular physical activity like walking after meals to improve insulin sensitivity
Follow up with your doctor or endocrinologist to discuss results and potential next steps
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Sample results
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