Understanding Lab Tests for Non-Hodgkin Lymphoma
Written by Private MD Labs Medical Writing Team • Last Updated: September 8, 2025
Non-Hodgkin lymphoma is a type of cancer that originates in the lymphatic system, which is part of the body's immune system. While the definitive diagnosis typically requires tissue biopsy and imaging studies, blood tests play a crucial role in detecting abnormal protein patterns and monitoring the disease's impact on the body.
Recommended Test
Kappa/Lambda Light Chains, Free with Ratio and Reflex to Immunofixation
This test measures free light chains (kappa and lambda) in the blood and calculates their ratio. In Non-Hodgkin lymphoma, this ratio may become abnormal due to the cancer's effect on immune cells that produce these proteins. An abnormal ratio can indicate disease presence or progression, making this test valuable for monitoring purposes.
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The Role of Blood Testing in Non-Hodgkin Lymphoma
Blood tests are fundamental for assessing protein abnormalities that can occur with lymphoma, monitoring disease progression, and evaluating treatment response. These tests help healthcare providers understand how the cancer is affecting the body's protein production and immune function.
Understanding Your Results
Abnormal kappa/lambda light chain ratios can suggest disruption in normal immune cell function, which may be associated with lymphoma. However, these changes can also occur in other conditions, so results must be interpreted alongside other clinical findings and diagnostic procedures.
Important Considerations
The information here is for educational purposes only and is not a substitute for professional medical advice. Always consult with a healthcare provider for diagnosis and treatment. Blood tests are supportive tools in lymphoma management but cannot replace comprehensive medical evaluation.
