Non-Hodgkin Lymphoma is a cancer that originates in the lymphatic system, which is part of the body's immune system. It is caused by abnormal growth of lymphocytes (white blood cells) that multiply uncontrollably and accumulate in lymph nodes and other tissues. The Kappa/Lambda Light Chains, Free with Ratio and Reflex to Immunofixation is the most important blood test for monitoring this condition because it detects abnormal protein patterns produced by cancerous immune cells.
3303 reviews
90-day money-back guarantee
Lab order in minutes
Save a trip to the doctor
Low prices since 2005
Labs within 2 miles
Non-Hodgkin Lymphoma is caused by genetic mutations in lymphocytes (B cells or T cells) that lead to uncontrolled cell growth and accumulation in the lymph nodes, spleen, and other organs. Risk factors include infections like Epstein-Barr virus, Helicobacter pylori, hepatitis C, and HIV, as well as autoimmune diseases and exposure to certain chemicals or radiation. While the exact trigger for these mutations is often unknown, weakened immune systems and chronic inflammation significantly increase the risk of developing this blood cancer.
The Kappa/Lambda Light Chains, Free with Ratio and Reflex to Immunofixation is the most important blood test for monitoring Non-Hodgkin Lymphoma because it detects abnormal protein production by cancerous lymphocytes. This test measures free kappa and lambda light chains in your blood and calculates their ratio, which becomes abnormal when lymphoma affects your immune cells. While tissue biopsy remains essential for initial diagnosis, this blood test is crucial for tracking disease progression, evaluating treatment response, and detecting potential relapse. The immunofixation reflex helps identify specific abnormal proteins that may indicate active disease or complications.
You should get tested if you notice persistent swollen lymph nodes in your neck, armpits, or groin that last more than two weeks, unexplained fever or night sweats, sudden weight loss without dieting, or extreme fatigue that interferes with daily activities. Testing is also important if you experience persistent abdominal pain or swelling, frequent infections, or if you have a weakened immune system due to HIV, organ transplant, or autoimmune conditions. Early detection through blood work can help your healthcare provider assess abnormal protein patterns and determine if further evaluation is needed.
Save a trip to the doctor, go directly to the lab
Instant orders, results often overnight*
Results explained in simple language
Reviewed by US licensed doctors
Fast & confidential, we never sell or share your data
No insurance needed, transparent pricing
What this means
Your kappa/lambda ratio is elevated above the normal range, indicating an imbalance in the light chains produced by your immune system. While this doesn't automatically mean you have a serious condition, it suggests your body is producing more kappa light chains than lambda, which warrants further evaluation to rule out plasma cell disorders or monitor existing conditions.
Recommended actions
Follow up with your doctor to discuss these results and determine if additional testing is needed
Keep track of any new symptoms like bone pain, fatigue, or frequent infections
Maintain a healthy immune system through balanced nutrition, adequate sleep, and stress management
Schedule a retest in 3-6 months or as recommended by your healthcare provider to monitor trends
Not overhyped or overpriced. Just comprehensive blood testing made simple and for everyone.
3303 reviews
3303 reviews
Sample results
Your 24/7 Personal Lab Guide
Quick questions:
