Understanding Lab Tests for Non-celiac Gluten Sensitivity
Written by Private MD Labs Medical Writing Team • Last Updated: September 8, 2025
Non-celiac gluten sensitivity (NCGS) is a condition where individuals experience symptoms similar to celiac disease when consuming gluten, but without the characteristic intestinal damage. Unlike celiac disease, there is no single definitive blood test to diagnose NCGS. However, certain antibody tests can provide valuable supporting evidence and help healthcare providers assess immune responses to gluten.
Top Recommended Test
Gluten (f79) IgG
This test measures IgG antibodies produced in response to gluten consumption. People with non-celiac gluten sensitivity often produce these antibodies when consuming gluten, though without the intestinal damage seen in celiac disease. Increased levels of these antibodies can suggest an immune response to gluten and support the presence of this condition.
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The Role of Blood Testing in Non-celiac Gluten Sensitivity
Diagnosis of non-celiac gluten sensitivity is primarily based on symptom improvement when following a gluten-free diet, after ruling out celiac disease and wheat allergy. While blood tests cannot definitively diagnose NCGS, they are fundamental for measuring immune responses to gluten proteins and can support clinical assessment when used alongside other diagnostic criteria.
Other Relevant Tests
Gliadin (Deamidated) Antibody (IgA)
This test measures IgA antibodies against deamidated gliadin, a component of gluten. While the relationship is less well-defined than in celiac disease, non-celiac gluten sensitivity can cause an immune response that may result in elevated levels of this antibody. However, the clinical significance requires careful interpretation by healthcare providers as more research is needed in this area.
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Understanding Your Results
It's important to note that elevated antibody levels alone do not confirm non-celiac gluten sensitivity. These tests should be interpreted alongside clinical symptoms, dietary response, and other diagnostic considerations. A comprehensive approach including symptom tracking and dietary elimination trials remains essential for proper diagnosis.
Important Considerations
The information here is for educational purposes only and is not a substitute for professional medical advice. Always consult with a healthcare provider for diagnosis and treatment. Proper evaluation should also rule out celiac disease and wheat allergy before considering non-celiac gluten sensitivity.
