Question 1

What is Non-celiac Gluten Sensitivity?

Accepted Answer

Non-celiac gluten sensitivity is a condition where individuals experience digestive symptoms, fatigue, and other reactions when consuming gluten-containing foods without the intestinal damage of celiac disease. It is caused by an immune response to gluten proteins found in wheat, barley, and rye, triggering IgG and IgA antibody production. The Gluten (f79) IgG test is the most important test for identifying immune responses to gluten in non-celiac gluten sensitivity.

Question 2

What causes non-celiac gluten sensitivity?

Accepted Answer

Non-celiac gluten sensitivity is caused by an immune response to gluten proteins found in wheat, barley, and rye. When people with this condition consume gluten, their immune system produces IgG and IgA antibodies against gluten and gliadin proteins, triggering inflammation and symptoms throughout the body. Unlike celiac disease, this immune reaction does not damage the small intestine, but it still causes real and uncomfortable symptoms like bloating, fatigue, brain fog, and digestive distress.

Question 3

What is the best test for non-celiac gluten sensitivity?

Accepted Answer

The Gluten (f79) IgG test is the most important test for non-celiac gluten sensitivity because it directly measures IgG antibodies your body produces in response to gluten consumption. When you have gluten sensitivity, elevated IgG levels indicate your immune system is reacting to gluten proteins. The Gliadin (Deamidated) Antibody (IgA) test provides additional supporting evidence by measuring IgA antibodies against specific gluten components. Together, these tests help identify immune responses to gluten and support diagnosis when combined with symptom tracking and dietary elimination trials.

Question 4

When should I get tested for non-celiac gluten sensitivity?

Accepted Answer

You should get tested if you experience digestive issues like bloating, gas, diarrhea, or stomach pain after eating bread, pasta, or other wheat-containing foods. Testing is also important if you notice fatigue, brain fog, headaches, or joint pain that seems connected to your diet. Get tested before starting a gluten-free diet, as eliminating gluten beforehand can cause antibody levels to drop and lead to false-negative results. If you have a family history of gluten-related conditions or autoimmune disorders, testing can provide valuable baseline information.

Question 5

What are the symptoms of non-celiac gluten sensitivity?

Accepted Answer

Symptoms of non-celiac gluten sensitivity include digestive problems like bloating, gas, abdominal pain, diarrhea, and constipation after eating gluten. Many people experience fatigue, brain fog, difficulty concentrating, and headaches. Other common symptoms include joint and muscle pain, skin problems like rashes or eczema, mood changes including anxiety and depression, and numbness or tingling in the hands and feet. Symptoms typically appear within hours to a few days after consuming gluten and improve when gluten is removed from the diet.

Question 6

Who is at risk for non-celiac gluten sensitivity?

Accepted Answer

People with a family history of celiac disease, autoimmune conditions, or food sensitivities are at higher risk for non-celiac gluten sensitivity. Those with irritable bowel syndrome often have underlying gluten sensitivity contributing to their symptoms. Women are diagnosed more frequently than men, and symptoms often emerge in adulthood, though they can occur at any age. People with other autoimmune conditions like Hashimoto thyroiditis, rheumatoid arthritis, or type 1 diabetes have increased risk of developing gluten sensitivity.

Question 7

What happens if non-celiac gluten sensitivity is left untreated?

Accepted Answer

Untreated non-celiac gluten sensitivity leads to chronic inflammation that affects multiple body systems over time. Ongoing digestive issues can result in nutrient malabsorption, causing deficiencies in iron, B vitamins, and other essential nutrients. Persistent inflammation increases the risk of developing autoimmune conditions and worsens existing ones. Many people experience progressive fatigue, cognitive difficulties, and reduced quality of life. The constant immune activation can contribute to chronic pain conditions, mood disorders, and weakened immune function, making you more susceptible to infections and other health problems.

Question 8

Can non-celiac gluten sensitivity be diagnosed with a blood test?

Accepted Answer

Blood tests like the Gluten (f79) IgG and Gliadin (Deamidated) Antibody (IgA) provide valuable supporting evidence for non-celiac gluten sensitivity by measuring immune responses to gluten. However, these tests alone cannot definitively diagnose the condition since there is no single diagnostic marker. Diagnosis requires a comprehensive approach that combines blood test results with symptom evaluation, dietary elimination trials, and symptom improvement on a gluten-free diet. Blood tests are most useful after ruling out celiac disease and wheat allergy, helping to confirm that your symptoms are related to an immune response to gluten.

Question 9

How is non-celiac gluten sensitivity treated?

Accepted Answer

Non-celiac gluten sensitivity is treated primarily through a strict gluten-free diet that eliminates wheat, barley, rye, and contaminated oats. Most people notice significant symptom improvement within weeks to months of removing gluten from their diet. Unlike celiac disease, some people with gluten sensitivity can tolerate small amounts of gluten occasionally without severe consequences, though this varies individually. Treatment also includes addressing nutrient deficiencies through supplementation, healing gut inflammation with probiotics and anti-inflammatory foods, and managing related symptoms. Working with a registered dietitian helps ensure nutritional adequacy while maintaining a gluten-free lifestyle.

Question 10

How can I prevent non-celiac gluten sensitivity?

Accepted Answer

Non-celiac gluten sensitivity cannot be completely prevented since genetic and immune factors play important roles. However, you can reduce your risk by maintaining a diverse diet rather than consuming excessive amounts of gluten-containing foods daily. Supporting gut health through probiotic-rich foods, adequate fiber, and limiting processed foods helps maintain a healthy immune response. If you have a family history of gluten-related conditions, monitoring for early symptoms and getting tested promptly allows for early intervention. Avoiding unnecessary antibiotic use, managing stress, and addressing gut infections quickly helps protect your digestive system and immune function.

Question 11

What natural remedies help with non-celiac gluten sensitivity?

Accepted Answer

Digestive enzymes containing DPP-IV can help break down gluten proteins if you are accidentally exposed, though they should not replace a gluten-free diet. Probiotics support gut healing and reduce inflammation caused by gluten sensitivity. Bone broth, glutamine supplements, and omega-3 fatty acids help repair intestinal lining damage and reduce inflammation. Ginger and peppermint tea soothe digestive symptoms, while turmeric and quercetin provide anti-inflammatory benefits. Adequate hydration, stress management through meditation or yoga, and sufficient sleep support your immune system and promote healing while following a gluten-free diet.

Question 12

How’s this work?

Accepted Answer

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Question 13

How do I know which test to get?

Accepted Answer

In the test options, find the test you want.
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Question 14

When will my lab results be available?

Accepted Answer

Most test results will be available within 1–3 business days. Once they're ready, we'll send an email and text message to let you know.
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Question 15

Is it possible to make changes to my lab order if I made a mistake with the name, date of birth, or any other details?

Accepted Answer

Absolutely! We totally understand that errors can happen. No worries, we're here to help you.
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Question 16

Do you accept health insurance?

Accepted Answer

Only HSA & FSA is accepted.
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Question 17

Can I cancel my order?

Accepted Answer

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Question 18

How can I find a lab location near me?

Accepted Answer

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Non-Celiac Gluten Sensitivity Blood Test

What is Non-celiac Gluten Sensitivity?

What causes non-celiac gluten sensitivity?

What is the best test for non-celiac gluten sensitivity?

When should I get tested for non-celiac gluten sensitivity?

References

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