Understanding Lab Tests for Nicotine Poisoning

Written by Private MD Labs Medical Writing Team • Last Updated: September 8, 2025

Nicotine poisoning is a serious condition that occurs when someone is exposed to toxic levels of nicotine, typically through ingestion of tobacco products, e-cigarettes, or nicotine replacement products. While diagnosis is primarily based on clinical symptoms and exposure history, laboratory testing plays a crucial supporting role in confirming exposure levels and assessing the severity of poisoning.

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Nicotine and Cotinine, LC/MS/MS, Urine

This highly sensitive test measures both nicotine and its metabolite cotinine in urine using advanced LC/MS/MS technology. Extremely elevated levels can confirm acute nicotine exposure and help healthcare providers assess the severity of poisoning, especially when patients present with symptoms like nausea, vomiting, increased heart rate, high blood pressure, or more severe complications.

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Why Lab Testing is Important for Nicotine Poisoning

Although there isn't a single blood test that diagnoses nicotine poisoning, laboratory testing is fundamental for confirming suspected exposure and measuring the extent of nicotine in the body. This information helps healthcare providers assess the severity of the poisoning and guide appropriate treatment decisions, especially in cases where the exposure history is unclear.

Understanding Nicotine Poisoning Symptoms

Nicotine poisoning can cause a range of symptoms including nausea, vomiting, diarrhea, rapid heart rate, elevated blood pressure, dizziness, and confusion. In severe cases, it can lead to seizures, respiratory depression, and other life-threatening complications. Laboratory confirmation of high nicotine levels supports clinical diagnosis and helps determine the appropriate level of medical intervention needed.

Important Considerations

Nicotine poisoning is a medical emergency that requires immediate professional medical attention. The information here is for educational purposes only and is not a substitute for emergency medical care. If you suspect nicotine poisoning, seek immediate medical attention or contact poison control.

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