Sample results
Nicotine addiction is a chronic condition characterized by compulsive tobacco use despite harmful consequences. It is caused by nicotine's effect on dopamine receptors in the brain, creating powerful physical and psychological dependence. The Nicotine and Cotinine LC/MS/MS Urine Test is the most important test for assessing the extent of tobacco exposure and monitoring cessation efforts.
Nicotine addiction is caused by nicotine's rapid effect on dopamine receptors in the brain's reward pathway, creating intense physical and psychological dependence. When you smoke or use tobacco products, nicotine reaches your brain within seconds, triggering a release of dopamine that produces pleasurable feelings and reinforces the urge to use tobacco again. Over time, your brain adapts to regular nicotine exposure by reducing natural dopamine production and increasing the number of nicotine receptors, which means you need more nicotine to achieve the same effect and experience withdrawal symptoms when you try to quit.
The Nicotine and Cotinine LC/MS/MS Urine Test is the most important test for nicotine addiction because it measures both nicotine and its primary metabolite cotinine, providing objective evidence of tobacco exposure levels. Cotinine remains detectable in urine much longer than nicotine itself, making it a more reliable indicator of smoking patterns and addiction severity. High cotinine levels can distinguish between light, moderate, and heavy tobacco use, which helps healthcare providers develop personalized cessation strategies. While this test does not diagnose addiction by itself, it provides crucial objective data that complements clinical assessment and helps monitor your progress during treatment.
You should get tested if you are attempting to quit smoking and want to monitor your progress, if you are using nicotine replacement therapy and need to assess appropriate dosing, if you are participating in a smoking cessation program that requires objective verification of tobacco use, or if your healthcare provider needs to evaluate the extent of your tobacco exposure to develop an effective treatment plan. Testing is also valuable if you have been exposed to secondhand smoke and want to measure nicotine levels in your system, or if you need documentation of tobacco use for insurance, employment, or medical purposes.
What this means
Your cotinine test came back negative, meaning no cotinine was detected in your urine. This confirms that you have not been exposed to tobacco smoke recently and indicates successful tobacco-free status, whether from quitting smoking or avoiding secondhand smoke exposure.
Recommended actions
Continue avoiding tobacco products and secondhand smoke environments
Maintain healthy habits that support your tobacco-free lifestyle like regular exercise and stress management
Consider retesting in 6-12 months to document ongoing tobacco-free status for insurance or employment
Share your success with others who may be trying to quit smoking for motivation
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Sample results
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