Neutropenia is a condition characterized by abnormally low levels of neutrophils, a type of white blood cell essential for fighting bacterial infections. It is caused by bone marrow disorders, chemotherapy, certain medications, autoimmune diseases, or severe infections that destroy neutrophils faster than they can be produced. The Complete Blood Count (CBC) with Differential is the most important test for diagnosing neutropenia because it directly measures absolute neutrophil count and determines infection risk severity.
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Neutropenia is caused by conditions that damage the bone marrow or destroy neutrophils faster than they can be produced. Common causes include chemotherapy and radiation therapy for cancer, which damage bone marrow cells, certain medications like antibiotics (sulfonamides, penicillins) and anti-seizure drugs, autoimmune disorders where the body attacks its own neutrophils, viral infections like HIV and hepatitis, bone marrow diseases such as leukemia and myelodysplastic syndromes, and severe bacterial infections that consume neutrophils rapidly. Some people are born with congenital neutropenia due to genetic mutations.
The Complete Blood Count (CBC) with Differential is the most important test for neutropenia because it measures your absolute neutrophil count (ANC), which is the definitive diagnostic marker. This test provides a complete picture of all your white blood cell types, red blood cells, and platelets, allowing doctors to identify low neutrophil levels and classify the severity as mild (1,000-1,500 cells per microliter), moderate (500-1,000 cells/ÎŒL), or severe (below 500 cells/ÎŒL). The lower your neutrophil count, the higher your risk for serious bacterial infections. If neutropenia is confirmed, your doctor may order additional tests like bone marrow biopsy or genetic testing to identify the underlying cause.
You should get tested if you experience frequent or severe infections, especially bacterial infections that keep coming back, fever without an obvious source, mouth sores or gum infections that do not heal, skin infections or slow-healing wounds, or unusual fatigue and weakness. Testing is especially important if you are undergoing chemotherapy, taking medications known to affect white blood cell counts, have an autoimmune disease, or have a family history of blood disorders. Anyone with recurrent infections despite antibiotic treatment should request a CBC with differential to check neutrophil levels.
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What this means
Your hemoglobin is slightly below the optimal range, indicating mild anemia. This means your blood isn't carrying quite enough oxygen to your body's tissues, which can explain feelings of fatigue, weakness, or occasional shortness of breath. With proper nutrition and possibly supplementation, this typically improves within a few months.
Recommended actions
Increase iron-rich foods like lean red meat, beans, lentils, and dark leafy greens
Pair iron sources with vitamin C foods (citrus, tomatoes, bell peppers) to boost absorption
Consider an iron supplement after consulting with your doctor about the right dosage
Retest in 8-12 weeks to monitor improvement after dietary changes
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