Neural tube defects are serious birth defects affecting the brain, spine, or spinal cord, including spina bifida and anencephaly. These conditions develop when the neural tube fails to close properly during the first month of pregnancy due to inadequate folate levels in the mother. The Folate, RBC test is the most important test for prevention, measuring long-term folate stores critical for proper neural tube development.
90-day money-back guarantee
Lab order in minutes
Save a trip to the doctor
Low prices since 2005
Labs within 2 miles
Neural tube defects are caused by inadequate folate (vitamin B9) levels in the mother during the critical first 28 days of pregnancy when the neural tube develops and closes. Folate is essential for DNA synthesis and cell division during rapid fetal development. Without sufficient folate, the neural tube may fail to close completely, resulting in conditions like spina bifida, where the spinal column does not fully close, or anencephaly, where major portions of the brain and skull do not develop. Other contributing factors include certain medications, diabetes, obesity, and genetic predispositions, but folate deficiency remains the primary preventable cause.
The Folate, RBC (red blood cell folate) test is the most important test for neural tube defect prevention because it measures long-term folate stores in your body rather than just recent dietary intake. This test provides a more accurate picture of your folate status over the past 2-3 months, which is critical since neural tube development occurs very early in pregnancy, often before you know you are pregnant. Women planning pregnancy should have their RBC folate levels checked to ensure adequate stores before conception. If levels are low, your healthcare provider can recommend appropriate folic acid supplementation to reduce neural tube defect risk by up to 70 percent. This simple blood test can make the difference between a healthy pregnancy and a devastating birth defect.
You should get tested for folate levels if you are planning to become pregnant, are of childbearing age and sexually active, have a history of neural tube defects in previous pregnancies, or have a family history of these conditions. Testing is especially important at least 3 months before trying to conceive, as it takes time to build adequate folate stores in your body. You should also consider testing if you take medications that interfere with folate absorption, have been diagnosed with malabsorption conditions, follow a restricted diet, or have not been taking prenatal vitamins regularly. Early testing and supplementation can prevent up to 70 percent of neural tube defects.
Save a trip to the doctor, go directly to the lab
Instant orders, results often overnight*
Results explained in simple language
Reviewed by US licensed doctors
Fast & confidential, we never sell or share your data
No insurance needed, transparent pricing
What this means
Your red blood cell folate levels are slightly below the optimal range, which may indicate a long-term folate deficiency. While not critically low, this could contribute to fatigue, weakness, and reduced energy levels over time. Low folate can also affect red blood cell production and overall cellular health.
Recommended actions
Increase intake of folate-rich foods like dark leafy greens, legumes, and fortified cereals
Consider a daily folic acid supplement after consulting with your healthcare provider
Limit alcohol consumption, as it interferes with folate absorption
Retest in 8-12 weeks after making dietary changes or starting supplementation
Not overhyped or overpriced. Just comprehensive blood testing made simple and for everyone.
3303 reviews
Sample results
Your 24/7 Personal Lab Guide
Quick questions:
