Understanding Lab Tests for Neonatal Lupus
Written by Private MD Labs Medical Writing Team • Last Updated: September 8, 2025
Neonatal lupus is a rare condition that affects newborns whose mothers have certain autoimmune antibodies. While there is no blood test to directly diagnose neonatal lupus in the newborn after birth, testing is fundamental for identifying maternal antibodies that can cross the placenta and cause this condition in the developing fetus.
Recommended Test
Sjögren's Antibodies (SS-A, SS-B)
This test detects SS-A and SS-B antibodies in the mother's blood. The presence of SS-B antibodies is particularly important as these can cross the placenta during pregnancy and cause neonatal lupus in the developing fetus. Identifying these antibodies helps healthcare providers assess risk and implement appropriate monitoring strategies.
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Why Maternal Antibody Testing is Critical
Neonatal lupus occurs when specific maternal autoimmune antibodies cross the placenta during pregnancy and affect the developing baby. Testing pregnant mothers who have autoimmune conditions helps assess the risk and allows for appropriate monitoring and management during pregnancy and after birth.
Understanding the Connection
Mothers with autoimmune disorders such as systemic lupus erythematosus or Sjögren's syndrome may carry antibodies that can affect their unborn children. Early detection of these antibodies allows for enhanced prenatal care and preparation for potential complications in the newborn.
Important Considerations
The information here is for educational purposes only and is not a substitute for professional medical advice. Always consult with a healthcare provider for diagnosis and treatment.
