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Muscle damage is the breakdown of muscle tissue caused by trauma, intense exercise, muscle diseases, or rhabdomyolysis. It occurs when muscle cells release enzymes like aspartate aminotransferase (AST) and metabolic byproducts like creatinine into the bloodstream. The Aspartate Aminotransferase (AST/SGOT) test is the most important test for diagnosis because it directly measures the enzyme released when muscle cells are damaged.
Muscle damage is caused by direct trauma, intense or prolonged exercise, muscle diseases like muscular dystrophy, infections, medications (especially statins), and conditions like rhabdomyolysis where muscle tissue breaks down rapidly. When muscle cells are injured, they release enzymes like AST and creatine kinase, along with metabolic byproducts like creatinine and myoglobin into your bloodstream. Severe muscle damage can even affect your kidneys when myoglobin clogs the kidney filters, making early detection through blood testing essential for preventing complications.
The Aspartate Aminotransferase (AST/SGOT) test is the most important test for muscle damage because it measures the enzyme released directly from damaged muscle cells into your bloodstream. When muscle tissue breaks down from injury, exercise, or disease, AST levels rise significantly, making it an excellent marker for detecting and monitoring muscle injury. For comprehensive assessment, the Protein Electrophoresis and Total Protein Random Urine test measures creatinine levels in urine to detect muscle breakdown products, while the AspirinWorks 11-dhTXB2 with Creatinine test evaluates blood creatinine levels to assess the severity of muscle damage and potential kidney impact from conditions like rhabdomyolysis.
You should get tested if you experience unexplained muscle pain, weakness, or stiffness that lasts more than a few days, especially after intense workouts or starting new medications like statins. Get tested immediately if you notice dark brown or tea-colored urine, which indicates myoglobin release from severe muscle breakdown, or if you have extreme muscle soreness with swelling and reduced range of motion. Athletes recovering from injuries, people with muscle diseases like muscular dystrophy, and anyone experiencing muscle symptoms after infections or crush injuries should also get tested to monitor muscle enzyme levels and prevent complications.
What this means
Your AST levels are slightly elevated above the normal range. While this is a mild elevation, it may indicate some stress or minor damage to your liver, heart, or muscle tissues that warrants attention and lifestyle modifications.
Recommended actions
Limit or avoid alcohol consumption completely for several weeks
Maintain a healthy weight through balanced diet rich in vegetables, fruits, and lean proteins
Avoid unnecessary medications or supplements that can stress the liver
Retest in 4-6 weeks to monitor trends and ensure levels are improving
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