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Meningococcal meningitis is a severe bacterial infection causing inflammation of the protective membranes covering the brain and spinal cord. It is caused by Neisseria meningitidis bacteria that invade the bloodstream and central nervous system. The Complement Component C4 test is the most important blood test for assessing immune response severity during active infection.
Meningococcal meningitis is caused by the bacteria Neisseria meningitidis, which spreads through respiratory droplets from coughing, sneezing, or close contact with infected individuals. The bacteria travel through the bloodstream and cross the blood-brain barrier to infect the meninges, the protective membranes surrounding the brain and spinal cord. This infection triggers a severe inflammatory response that can lead to brain damage, hearing loss, or death if not treated immediately with antibiotics.
The Complement Component C4 test is the most important blood test for meningococcal meningitis because it measures how actively your immune system is fighting the infection. During acute infection, the complement system becomes highly activated to attack the bacteria, which causes C4 levels to drop significantly. Low C4 levels indicate a severe, ongoing immune response and help doctors understand the infection severity and guide aggressive treatment decisions. While cerebrospinal fluid analysis remains the primary diagnostic method, complement testing provides crucial information about immune system function and potential complications.
You should get tested immediately if you experience sudden high fever combined with severe headache, stiff neck, sensitivity to light, or confusion. Other warning signs include a purple or red rash that does not fade when pressed, nausea with vomiting, difficulty staying awake, or seizures. Meningococcal meningitis is a medical emergency that progresses rapidly, sometimes within hours, so immediate medical attention and testing are critical if you have been exposed to someone with the infection or develop these symptoms.
What this means
Your C4 levels in pleural fluid are below the normal range, which suggests that an immune-related condition may be contributing to the fluid buildup around your lungs. This finding often points to autoimmune disorders like lupus or rheumatoid arthritis affecting the pleural lining. Your doctor will likely recommend additional immune system testing to identify the specific condition and develop an appropriate treatment plan.
Recommended actions
Follow up with a rheumatologist or pulmonologist for comprehensive evaluation
Get additional blood tests for autoimmune markers like ANA and rheumatoid factor
Keep a symptom diary tracking breathing difficulties, chest pain, and fatigue
Discuss treatment options that address both the immune condition and pleural effusion
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