Understanding Lab Tests for Malignant Hyperthermia
Written by Private MD Labs Medical Writing Team • Last Updated: September 8, 2025
Malignant hyperthermia is a rare, life-threatening reaction to certain anesthesia drugs that causes rapid increase in body temperature and muscle rigidity. This condition is diagnosed clinically during surgery based on symptoms and patient response. There is no single blood test that directly diagnoses malignant hyperthermia; however, lab testing plays a supportive role in identifying potential risk factors.
Recommended Test
Suxamethonium (succinylcholine) (rc202) IgE
This test measures IgE antibodies against succinylcholine, a neuromuscular blocking agent commonly used during anesthesia. While not directly diagnostic for malignant hyperthermia, elevated IgE levels indicate an allergy to this drug, and individuals with such allergies may have an increased risk of developing malignant hyperthermia reactions during surgery.
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Why Blood Testing Can Be Important
While malignant hyperthermia cannot be predicted or diagnosed through routine blood tests, testing for allergies to specific anesthesia medications can help identify individuals who may be at increased risk. This information is valuable for anesthesiologists when planning surgical procedures.
Important Considerations
The information here is for educational purposes only and is not a substitute for professional medical advice. Always consult with a healthcare provider for diagnosis and treatment. If you have a family history of malignant hyperthermia, inform your anesthesiologist before any surgical procedure.
