Understanding Lab Tests for Malignancy-associated Hypercalcemia
Written by Private MD Labs Medical Writing Team • Last Updated: September 8, 2025
Malignancy-associated hypercalcemia is a condition where certain types of cancer cause elevated calcium levels in the blood. This occurs when tumors produce hormone-like substances that disrupt normal calcium regulation. Blood tests are essential for diagnosing this condition and distinguishing it from other causes of high calcium levels.
Recommended Test
Parathyroid Hormone (PTH), Intact
This test measures the level of intact parathyroid hormone in the blood. In malignancy-associated hypercalcemia, some tumors produce PTH-like substances that can elevate both PTH levels and calcium levels. This test helps distinguish cancer-related hypercalcemia from other causes by identifying abnormal hormone patterns associated with certain malignancies.
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How Cancer Can Affect Calcium Levels
Some cancers can produce substances that mimic parathyroid hormone (PTH) or other calcium-regulating factors. This leads to increased calcium absorption and release from bones, resulting in dangerously high blood calcium levels. Identifying the underlying mechanism is crucial for proper treatment.
Understanding Your Results
Elevated PTH levels combined with high calcium may indicate malignancy-associated hypercalcemia, especially in patients with known cancer or suspicious symptoms. However, other conditions can also cause similar patterns, making professional medical interpretation essential for accurate diagnosis and appropriate treatment planning.
Important Considerations
The information here is for educational purposes only and is not a substitute for professional medical advice. Always consult with a healthcare provider for diagnosis and treatment.
