Written by Private MD Labs Medical Writing Team • Last Updated: September 8, 2025
Prostate-Specific Antigen (PSA) is a protein produced by the prostate gland. While elevated PSA levels often receive attention, unusually low PSA levels can also provide important health information and may indicate underlying health concerns that warrant medical evaluation.
This blood test directly measures PSA levels in the blood. While much attention focuses on elevated PSA levels, very low levels can also be medically significant. Extremely low PSA levels may be associated with poor overall health status or risk factors for serious illnesses, making regular monitoring important for comprehensive health assessment.
PSA levels naturally vary among men and typically increase with age. However, extremely low PSA levels, particularly when significantly below normal ranges for a man's age group, may be associated with certain health conditions or risk factors that require medical assessment.
Very low PSA levels can sometimes indicate poor overall health status or may be associated with certain medications, hormonal changes, or other underlying conditions. Regular monitoring through blood testing helps healthcare providers assess prostate health and overall wellness as part of comprehensive health management.
PSA levels should always be interpreted by a healthcare provider who can consider your individual health history, age, medications, and other factors. What constitutes a concerning low level varies among individuals, and your doctor can determine if further evaluation or monitoring is needed.
The information here is for educational purposes only and is not a substitute for professional medical advice. Always consult with a healthcare provider for proper interpretation of PSA results and appropriate follow-up care.