Sample results
Longevity refers to the length of an individual's lifespan and their ability to maintain health as they age. It is influenced by genetic variations in genes like ApoE, which affects cholesterol metabolism, cardiovascular health, and cellular aging processes. The ApoE Genotype test is the most important genetic test for longevity assessment because it identifies inherited factors associated with extended lifespan.
Differences in longevity are caused by a combination of genetic variations, lifestyle factors, and environmental influences. Genetic factors account for approximately 20-30% of lifespan variation, with specific genes like ApoE, FOXO3, and CETP playing crucial roles in cellular aging, metabolism, and disease resistance. The remaining 70-80% is influenced by modifiable factors including diet, exercise, stress management, sleep quality, social connections, and exposure to environmental toxins throughout life.
The ApoE Genotype test is the most important genetic test for longevity assessment because it identifies which variant of the ApoE gene you carry, particularly the longevity-associated Δ2 allele. This test analyzes how your body metabolizes cholesterol and fats, which directly impacts cardiovascular health and brain aging. People with the Δ2 variant typically have lower cholesterol levels, reduced risk of Alzheimer's disease, and statistically longer lifespans compared to those with Δ3 or Δ4 variants. While genetic testing provides insights into inherited predispositions, it should be combined with lifestyle assessments and standard health markers like cholesterol panels, inflammation markers, and metabolic function tests for a comprehensive longevity evaluation.
You should get tested if you want to understand your genetic predisposition for healthy aging and make informed lifestyle decisions based on your unique biology. Testing is particularly valuable if you have a family history of early cardiovascular disease, Alzheimer's disease, or exceptional longevity, as genetic factors may play a significant role. Consider testing in your 30s or 40s when you can still implement preventive strategies, or at any age if you are developing a personalized health optimization plan with your healthcare provider.
What this means
Your APOE genotype is 3/4, meaning you have one copy of the APOE4 variant. This increases your risk for Alzheimer's disease and may affect how your body processes cholesterol. While this is a risk factor rather than a certainty, it's valuable information that allows you to take proactive steps to protect your brain and heart health.
Recommended actions
Adopt a Mediterranean-style diet rich in fish, olive oil, vegetables, and whole grains
Engage in regular aerobic exercise at least 150 minutes per week
Monitor and manage cholesterol, blood pressure, and blood sugar levels closely
Stay mentally and socially active through learning, hobbies, and social engagement
Prioritize quality sleep and stress management techniques
Not overhyped or overpriced. Just comprehensive blood testing made simple and for everyone.
Sample results
Your 24/7 Personal Lab Guide
Quick questions: