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Liver disease encompasses conditions that impair liver function, including hepatitis, cirrhosis, fatty liver disease, and liver cancer. It is caused by viral infections (hepatitis B and C), alcohol abuse, autoimmune disorders, genetic conditions like alpha-1-antitrypsin deficiency, and metabolic dysfunction. The Liver Function Profile is the most important test for diagnosis because it measures key liver enzymes (AST and ALT), proteins (albumin and globulin), bilirubin levels, and alkaline phosphatase to provide a complete assessment of liver health.
Liver disease is caused by viral infections (hepatitis B and C viruses), chronic alcohol abuse, autoimmune disorders where the immune system attacks liver cells, genetic conditions like alpha-1-antitrypsin deficiency and hemochromatosis, and metabolic dysfunction including non-alcoholic fatty liver disease. Toxins from medications, environmental pollutants, and certain herbs can also damage liver cells. Obesity and diabetes significantly increase the risk of fatty liver disease, which can progress to cirrhosis if left untreated.
The Liver Function Profile is the most important test for liver disease because it measures key liver enzymes (ALT and AST) that leak into the bloodstream when liver cells are damaged, proteins (albumin and globulin) that reflect the liver's ability to synthesize essential substances, bilirubin levels that indicate how well the liver processes waste products, and alkaline phosphatase that signals bile duct problems. This comprehensive panel can detect hepatitis, cirrhosis, fatty liver disease, and bile duct obstructions. For specific concerns, the ALT test is the most sensitive marker for liver cell injury, while the Prothrombin Time (PT/INR) assesses how well your liver produces clotting factors, which is critical for evaluating advanced liver disease.
You should get tested if you experience yellowing of the skin or eyes (jaundice), persistent fatigue and weakness, abdominal pain or swelling in the upper right side, unexplained weight loss, dark urine or pale stools, easy bruising or bleeding, or itchy skin. Get tested immediately if you have a history of heavy alcohol use, have been exposed to hepatitis viruses, take medications known to affect the liver, have diabetes or obesity, or have a family history of liver disease. Early detection through blood testing allows for effective management before irreversible damage occurs.
What this means
Your ALT level is slightly elevated above the optimal range, which may indicate mild liver inflammation or stress. This is commonly seen with fatty liver, alcohol use, certain medications, or metabolic conditions, and while not immediately alarming, it suggests your liver could benefit from some extra support.
Recommended actions
Reduce or eliminate alcohol consumption and limit processed foods
Incorporate regular exercise and work toward a healthy weight if needed
Increase intake of liver-supporting foods like leafy greens, beets, and cruciferous vegetables
Retest in 3-6 months to monitor improvement after lifestyle changes
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