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Liver cirrhosis is a serious condition where healthy liver tissue is gradually replaced by scar tissue, preventing the liver from functioning properly. It is caused by chronic viral infections like Hepatitis B, chronic alcohol abuse, fatty liver disease, and autoimmune conditions that damage liver cells over time. The Hepatitis Be Antigen test is the most important test for identifying active Hepatitis B virus replication, a major risk factor for developing cirrhosis.
Liver cirrhosis is caused by long-term liver damage from chronic viral infections like Hepatitis B and Hepatitis C, excessive alcohol consumption, non-alcoholic fatty liver disease, and autoimmune liver diseases. When your liver is repeatedly injured over months or years, scar tissue gradually replaces healthy liver cells, making it harder for your liver to do its job of filtering toxins, producing proteins, and helping with digestion. Chronic Hepatitis B infection is one of the leading causes worldwide, as the virus continuously attacks liver cells, triggering inflammation and progressive scarring that eventually leads to cirrhosis.
The Hepatitis Be Antigen test is the most important blood test for liver cirrhosis because it detects active Hepatitis B virus replication, which is a major cause of progressive liver damage and scarring. This test shows whether the virus is actively multiplying in your body, which helps determine your risk for developing cirrhosis and guides treatment decisions. Additionally, the Hep B Core Antibody IgM test is essential for identifying recent or acute Hepatitis B infections that could lead to chronic liver disease. While no single blood test directly diagnoses cirrhosis itself, these tests identify one of the most common underlying causes, allowing for early intervention to slow or prevent progression to advanced cirrhosis. Your doctor may also order liver function tests, imaging studies, or a liver biopsy for definitive diagnosis.
You should get tested if you have a history of chronic Hepatitis B or C infection, drink alcohol heavily or regularly over many years, have been diagnosed with fatty liver disease, or experience symptoms like persistent fatigue, jaundice (yellowing of skin or eyes), or unexplained abdominal swelling. Early testing is critical because cirrhosis often develops silently over years without obvious symptoms, and identifying the underlying cause early can help prevent further liver damage. If you have risk factors like a family history of liver disease, diabetes, or obesity, getting tested can catch problems before they progress to irreversible scarring.
What this means
Your HBeAg test came back negative, meaning the Hepatitis B virus is not actively replicating at high levels in your liver. This is a favorable result indicating lower viral activity and reduced infectivity to others. If you have chronic Hepatitis B, this may suggest your infection is in a less active phase.
Recommended actions
Continue regular monitoring of your Hepatitis B status with your doctor
Avoid alcohol completely to protect your liver from further damage
Maintain a healthy diet rich in vegetables, lean proteins, and whole grains
Retest HBeAg and other Hepatitis B markers every 6-12 months as recommended
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