Light chain disease is a rare plasma cell disorder characterized by the overproduction of immunoglobulin light chains that can deposit in organs and tissues. It is caused by abnormal plasma cells in the bone marrow producing excessive amounts of kappa or lambda light chains without complete antibody molecules. The Protein Electrophoresis with Total Protein and Reflex to IFE, Serum is the most important test for diagnosis because it identifies and characterizes the specific abnormal light chains in the blood.
3303 reviews
90-day money-back guarantee
Lab order in minutes
Save a trip to the doctor
Low prices since 2005
Labs within 2 miles
Light chain disease is caused by abnormal plasma cells in the bone marrow that produce excessive amounts of immunoglobulin light chains. These plasma cells undergo genetic mutations that cause them to multiply uncontrollably and produce only the light chain portions (kappa or lambda) of antibodies rather than complete immunoglobulin molecules. The excess light chains circulate in the bloodstream and can deposit in various organs including the kidneys, heart, liver, and nerves, leading to organ damage and dysfunction over time.
The Protein Electrophoresis with Total Protein and Reflex to IFE, Serum is the most important test for light chain disease because it detects and identifies the specific type of abnormal light chains in your blood. This comprehensive test first uses protein electrophoresis to separate blood proteins by electrical charge, creating a pattern that reveals abnormalities. When irregular patterns suggest abnormal proteins, the test automatically performs immunofixation electrophoresis (IFE), which provides detailed identification of whether you have excess kappa or lambda light chains. This two-step approach is essential because routine blood work cannot detect these abnormal proteins, and accurate identification of the light chain type is critical for diagnosis and treatment planning.
You should get tested if you experience unexplained kidney problems, persistent protein in your urine, unexplained fatigue or weakness, swelling in your legs or ankles, or if you have a family history of plasma cell disorders or multiple myeloma. Testing is also important if you have abnormal protein levels on routine blood work that cannot be explained, unexplained heart problems or irregular heartbeat, or numbness and tingling in your hands and feet. Early detection through blood testing is crucial because light chain deposits can cause irreversible organ damage if left untreated, and identifying the condition early allows for more effective treatment options.
Save a trip to the doctor, go directly to the lab
Instant orders, results often overnight*
Results explained in simple language
Reviewed by US licensed doctors
Fast & confidential, we never sell or share your data
No insurance needed, transparent pricing
What this means
Your total protein level is slightly below the optimal range. While this is often not concerning on its own, it may indicate reduced protein intake, absorption issues, or increased protein loss. This finding works together with your protein electrophoresis pattern to give a complete picture of your protein health.
Recommended actions
Ensure adequate daily protein intake from varied sources like lean meats, fish, eggs, and legumes
Stay well-hydrated and maintain a balanced diet with sufficient calories
Consider tracking your protein intake to ensure you're meeting daily needs (typically 0.8g per kg body weight)
Retest in 3-6 months to monitor trends, especially if symptoms persist
Not overhyped or overpriced. Just comprehensive blood testing made simple and for everyone.
3303 reviews
3303 reviews
Sample results
Your 24/7 Personal Lab Guide
Quick questions:
