Understanding Lab Tests for Lack of Immunity to Hepatitis B
Written by Private MD Labs Medical Writing Team • Last Updated: September 8, 2025
Hepatitis B is a viral infection that affects the liver and can cause both acute and chronic disease. Immunity to Hepatitis B can be acquired through vaccination or previous infection. Determining your immune status is crucial for preventing future infections, especially if you're at higher risk of exposure.
Recommended Test
Hepatitis B Surface Antibody Test
This test measures the presence of Hepatitis B surface antibodies in your blood. If these antibodies are not detected, it indicates that you have never been infected with Hepatitis B and lack immunity, making you susceptible to future Hepatitis B infections. A negative result suggests you may benefit from vaccination to develop protective immunity.
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How Blood Tests Determine Hepatitis B Immunity
Unlike many conditions that are diagnosed after symptoms appear, Hepatitis B immunity status is determined through specific blood testing that measures antibodies in your system. This testing can reveal whether you have protective immunity from vaccination or previous infection, or if you remain susceptible to the virus.
Understanding Your Results
If your Hepatitis B Surface Antibody test shows no detectable antibodies, this confirms a lack of immunity to Hepatitis B. In this case, your healthcare provider will likely recommend vaccination with the Hepatitis B vaccine series to develop protective antibodies and prevent future infection.
Who Should Consider Testing
Healthcare workers, individuals with multiple sexual partners, people who inject drugs, those living with someone who has Hepatitis B, and travelers to areas with high Hepatitis B prevalence should consider testing to determine their immune status and need for vaccination.
Important Considerations
The information here is for educational purposes only and is not a substitute for professional medical advice. Always consult with a healthcare provider for diagnosis, treatment, and vaccination recommendations.
