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Kidney disease is a condition where the kidneys gradually lose their ability to filter waste and excess fluid from the blood. It is caused by damage to the nephrons, the filtering units in the kidneys, often resulting from diabetes, high blood pressure, or chronic inflammation. The Comprehensive Metabolic Profile with eGFR is the most important test for diagnosis because it measures creatinine levels and estimated glomerular filtration rate, which directly assess kidney function.
Kidney disease is caused by damage to the nephrons, the tiny filtering units inside your kidneys that remove waste and excess fluid from your blood. Diabetes and high blood pressure are the two most common causes, as prolonged high blood sugar and elevated blood pressure damage the delicate blood vessels in the kidneys. Other causes include chronic glomerulonephritis (kidney inflammation), polycystic kidney disease, prolonged obstruction of the urinary tract, recurrent kidney infections, and autoimmune diseases like lupus.
The Comprehensive Metabolic Profile with eGFR is the most important test for kidney disease because it measures creatinine levels and calculates your estimated glomerular filtration rate (eGFR), which directly shows how well your kidneys are filtering waste from your blood. This panel also checks electrolyte balance, blood glucose, and protein levels, all of which become abnormal when kidneys are not functioning properly. Additional tests like the Urea Nitrogen (BUN) test help confirm kidney dysfunction by measuring waste products that should be filtered out, while the Calcium, Ionized, Serum and Magnesium, Serum tests assess mineral metabolism complications that occur as kidney disease progresses.
You should get tested if you have diabetes or high blood pressure, as these are the leading causes of kidney disease and regular monitoring is essential. Other reasons to test include if you notice swelling in your feet, ankles, or hands, changes in urination frequency or color, persistent fatigue, difficulty concentrating, or poor appetite. You should also consider testing if you have a family history of kidney disease, are over 60 years old, have heart disease, or take medications that can affect kidney function like lithium or long-term use of NSAIDs.
What this means
Your eGFR is slightly below the optimal range, indicating your kidneys may not be filtering waste as efficiently as they should. This could be an early sign of reduced kidney function that warrants closer monitoring and lifestyle adjustments to prevent further decline.
Recommended actions
Stay well-hydrated by drinking plenty of water throughout the day
Reduce sodium intake and limit processed foods to ease kidney workload
Maintain healthy blood pressure through diet, exercise, and stress management
Retest in 3-6 months to monitor kidney function trends
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