Understanding Lab Tests for Interference with Lab Tests
Written by Private MD Labs Medical Writing Team • Last Updated: September 8, 2025
Lab test interference occurs when substances in the body affect the accuracy of diagnostic test results, leading to falsely elevated or decreased values. While interference itself isn't diagnosed through blood tests, measuring specific interfering substances is fundamental for identifying potential causes of inaccurate results and ensuring reliable diagnostic outcomes.
Recommended Test
Biotin (Vitamin B7)
This test measures biotin levels in the blood to identify potential interference with laboratory tests. High biotin concentrations can significantly affect the accuracy of many biochemical assays, including thyroid function tests, cardiac markers, and hormone panels, leading to falsely elevated or decreased results depending on the specific test methodology used.
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Why Testing for Interfering Substances is Important
When lab results don't align with clinical symptoms or seem inconsistent, healthcare providers may suspect test interference. Blood testing for known interfering substances helps identify the source of inaccurate results, allowing for proper interpretation of diagnostic tests and preventing misdiagnosis or inappropriate treatment decisions.
Common Sources of Lab Test Interference
Various substances can interfere with lab tests, including medications, supplements, hormones, and other compounds. Identifying these interfering factors through targeted testing is essential for maintaining diagnostic accuracy and ensuring patient safety.
Understanding Biotin Interference
Biotin supplementation has become increasingly common, but many people are unaware that high biotin levels can interfere with numerous lab tests that use biotin-streptavidin technology. This interference can persist for days after supplementation, making biotin level testing valuable when unexplained or inconsistent lab results occur.
Important Considerations
The information here is for educational purposes only and is not a substitute for professional medical advice. Always consult with a healthcare provider for diagnosis and treatment. If you suspect lab test interference, discuss your medications and supplements with your healthcare provider before testing.
