Understanding Lab Tests for Immunodeficiency diseases
Written by Private MD Labs Medical Writing Team • Last Updated: September 8, 2025
Immunodeficiency diseases are conditions where the immune system's ability to fight infections and disease is compromised or absent. These conditions can be primary (present from birth due to genetic factors) or secondary (acquired due to illness, medications, or other factors). Blood tests play a crucial role in diagnosing these conditions by measuring various components of the immune system.
Top Recommended Test
IgG, IgA, Indirect Immunofluorescence
This test measures levels of IgG and IgA antibodies, which are essential for fighting infections. Low IgG levels can indicate serious immune deficiency conditions such as common variable immunodeficiency (CVID) or selective IgG subclass deficiency, making this a fundamental diagnostic test for immunodeficiency diseases.
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How Blood Tests Diagnose Immunodeficiency
Blood tests are the primary diagnostic tool for immunodeficiency diseases. They measure levels of antibodies (immunoglobulins), white blood cells, and immune system responses to specific pathogens. Abnormal levels of these components can indicate different types of immune deficiencies and help healthcare providers determine the most appropriate treatment approach.
Other Relevant Tests
Respiratory Allergy Profile Region VI: AL, AR, LA, MS
This test measures Immunoglobulin E (IgE) levels, which can be elevated in certain immunodeficiency diseases. High IgE levels may indicate conditions like hyper-IgE syndrome or other immune disorders that increase susceptibility to infections, helping to identify specific types of immune dysfunction.
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Phoma betae IgG
This test measures the immune system's specific response to the Phoma betae fungus by detecting IgG antibodies. Low levels may indicate that the immune system is not responding adequately to fungal pathogens, which can be a sign of immunodeficiency disease and impaired pathogen recognition.
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Understanding Your Results
Immunodeficiency testing typically involves measuring different types of antibodies and immune responses. Low levels of essential antibodies like IgG or IgA may indicate primary immunodeficiency, while abnormal IgE levels or poor responses to specific pathogens can suggest other immune system dysfunction. Your healthcare provider will interpret these results in the context of your symptoms and medical history.
Important Considerations
The information here is for educational purposes only and is not a substitute for professional medical advice. Always consult with a healthcare provider for diagnosis and treatment. Immunodeficiency diseases require specialized medical care and ongoing monitoring.
