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Natural immunity occurs when your immune system successfully fights off an infection and develops long-lasting protection against future infections from the same pathogen. It is caused by the production of specific antibodies that remain in your bloodstream after recovering from diseases like Hepatitis B, measles, or chickenpox. The Hepatitis B Core Antibody Total test is the most important test for confirming natural immunity to Hepatitis B virus.
Natural immunity is caused by your immune system's response to an actual infection with a virus or bacteria. When a pathogen like Hepatitis B virus, varicella-zoster virus (chickenpox), or measles virus enters your body, your immune system produces specialized proteins called antibodies that target and destroy the invader. These antibodies remain in your bloodstream for years or even your entire lifetime, providing ongoing protection against future infections from the same pathogen.
The Hepatitis B Core Antibody Total test is the most important test for confirming natural immunity to Hepatitis B because it detects Anti-HBc antibodies that only appear after actual infection, not vaccination. When this test shows positive results along with Hepatitis B surface antibodies (Anti-HBs), it confirms your body successfully fought off the virus and developed lasting protection. Different antibody tests are used for other infections - for example, varicella antibody tests for chickenpox immunity or measles antibody tests for measles immunity - but the Hepatitis B Core Antibody test is essential for determining if you have natural Hepatitis B immunity versus vaccine-induced immunity.
You should get tested if you suspect you had a past infection and want to confirm your immunity status before traveling to high-risk areas, starting a new healthcare job that requires immunity documentation, considering pregnancy and need to know your protection levels, or determining whether you need vaccination. Testing is also important if you were exposed to someone with an infectious disease and want to know if you're already protected, or if you're planning to donate blood or organs and need complete immunity records.
What this means
Your test came back negative, meaning no Hepatitis B Core antibodies were detected in your blood. This indicates you have not been exposed to or infected with Hepatitis B virus in the past. If you're at risk for exposure, you should consider getting vaccinated for protection.
Recommended actions
Discuss Hepatitis B vaccination with your doctor if you're at risk
Practice safe behaviors to avoid bloodborne pathogen exposure
Consider testing annually if you work in healthcare or have other risk factors
Maintain awareness of transmission routes including needles and unprotected contact
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