Understanding Lab Tests for IgA Nephropathy
Written by Private MD Labs Medical Writing Team • Last Updated: September 8, 2025
IgA Nephropathy, also known as Berger's disease, is a kidney disorder that occurs when immunoglobulin A (IgA) antibodies deposit in the kidneys, causing inflammation that impairs the kidneys' ability to filter waste, excess water, and electrolytes from the blood. While kidney biopsy remains the definitive diagnostic method, blood tests play a crucial supporting role in monitoring IgA levels and assessing immune system function.
Top Recommended Test
IgA
This test directly measures IgA antibody levels in the blood. Since IgA Nephropathy involves IgA deposits building up in the kidneys and causing inflammation, monitoring these levels is essential for understanding disease activity and tracking the immune system's response over time.
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The Role of Blood Testing in IgA Nephropathy
Although there isn't a single blood test that can definitively diagnose IgA Nephropathy, blood testing is fundamental for measuring immunoglobulin levels, particularly IgA, and monitoring the immune system's activity. These tests help healthcare providers assess disease progression, evaluate treatment effectiveness, and identify potential complications.
Other Relevant Tests
Immunoglobulins Panel, Serum
This comprehensive panel measures all major immunoglobulins including IgA, providing a complete picture of immune function. It's particularly valuable for IgA Nephropathy patients as it can detect elevated IgA levels and assess overall immune system balance that may contribute to kidney inflammation.
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IgG, IgA, Indirect Immunofluorescence
This specialized test uses immunofluorescence techniques to detect and measure IgA and IgG antibodies. It's particularly useful for identifying specific antibody patterns that may be associated with the IgA deposits causing kidney inflammation and damage in IgA Nephropathy.
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Celiac Disease Comprehensive Panel, Infant
This test is relevant because celiac disease can be associated with elevated IgA levels, which may contribute to IgA nephropathy development. High IgA levels can deposit in the kidneys, leading to the inflammation characteristic of this kidney disease, making screening for related conditions important.
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Understanding Your Results
Elevated IgA levels in blood tests may indicate increased risk for IgA deposits in the kidneys, but the presence of the disease itself requires additional evaluation including kidney function tests and potentially tissue examination. Regular monitoring of immunoglobulin levels helps track disease progression and treatment response.
Important Considerations
The information here is for educational purposes only and is not a substitute for professional medical advice. Always consult with a healthcare provider for proper diagnosis, treatment, and monitoring of IgA Nephropathy.
