IgA Nephropathy, also known as Berger's disease, is a kidney disorder where immunoglobulin A (IgA) antibodies deposit in the kidneys, causing inflammation that impairs waste filtration. It is caused by abnormal IgA antibodies that accumulate in the glomeruli (kidney filters), triggering an immune response that damages kidney tissue. The IgA blood test is the most important test for monitoring this condition because it directly measures the IgA antibody levels that deposit in the kidneys.
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IgA Nephropathy is caused by abnormal immunoglobulin A (IgA) antibodies that deposit in the glomeruli, the tiny filtering units of your kidneys. When these IgA antibodies accumulate, they trigger inflammation that damages the delicate kidney structures responsible for filtering waste and excess fluids from your blood. The exact reason why some people produce these abnormal IgA antibodies remains unclear, but genetic factors, infections, and immune system dysfunction all play a role in this process.
The IgA blood test is the most important test for monitoring IgA Nephropathy because it directly measures the levels of IgA antibodies circulating in your blood that deposit in the kidneys and cause inflammation. This test helps track disease activity and assess how your immune system is responding over time. The Immunoglobulins Panel, Serum is also essential as it measures all major immunoglobulins including IgA, giving a complete picture of your immune function and detecting elevated IgA levels that contribute to kidney damage. For more detailed analysis, the IgG, IgA, Indirect Immunofluorescence test uses specialized techniques to identify specific antibody patterns associated with the IgA deposits causing kidney inflammation.
You should get tested if you notice blood in your urine (especially during or after a cold or respiratory infection), persistent foamy urine indicating protein loss, swelling in your hands and feet, or high blood pressure that develops without clear cause. Testing is also important if you have a family history of IgA Nephropathy or kidney disease, as genetic factors increase your risk. Regular monitoring through blood tests helps catch kidney function changes early, allowing for timely treatment adjustments before significant kidney damage occurs.
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What this means
Your IgA levels are slightly below the optimal range, which may affect your immune system's ability to protect against infections in your gut and respiratory tract. While this is not necessarily alarming, lower IgA can make you more susceptible to digestive issues and recurring infections over time.
Recommended actions
Support gut health with probiotic-rich foods like yogurt, kefir, and fermented vegetables
Ensure adequate intake of vitamins A and D through diet or supplements to support immune function
Manage stress and prioritize 7-8 hours of quality sleep to strengthen immunity
Retest in 3-6 months to monitor trends and discuss results with your healthcare provider if symptoms persist
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