Idiopathic myxedema is a rare and severe form of hypothyroidism characterized by extreme thyroid hormone deficiency causing distinctive skin thickening, swelling, and a waxy appearance. It is caused by profound thyroid dysfunction that affects multiple body systems, particularly the skin and subcutaneous tissues. The Thyroid Peroxidase (TPO) and Thyroglobulin Antibodies test is the most important test for diagnosis because it identifies autoimmune factors that may contribute to this severe thyroid condition.
90-day money-back guarantee
Lab order in minutes
Save a trip to the doctor
Low prices since 2005
Labs within 2 miles
Idiopathic myxedema is caused by extreme thyroid hormone deficiency that leads to severe hypothyroidism with characteristic skin changes. The underlying mechanism involves profound disruption of thyroid function, which can result from autoimmune destruction of thyroid tissue, where the body produces antibodies against thyroid peroxidase and thyroglobulin. This severe thyroid dysfunction causes accumulation of mucopolysaccharides in the skin and subcutaneous tissues, leading to the distinctive thickening, swelling, and waxy appearance that defines this condition.
The Thyroid Peroxidase (TPO) and Thyroglobulin Antibodies test is the most important test for idiopathic myxedema because it detects autoimmune factors that may be driving the severe thyroid dysfunction. This comprehensive antibody panel measures both TPO antibodies and thyroglobulin antibodies, which can reveal autoimmune thyroid involvement even when other markers appear normal. While these antibodies are not always elevated in idiopathic myxedema, their presence provides crucial information about the underlying autoimmune processes contributing to the condition, helping healthcare providers develop targeted treatment strategies for this severe form of hypothyroidism.
You should get tested if you notice unusual skin thickening or swelling, especially on your face, hands, or legs with a waxy appearance. Testing is also important if you experience severe hypothyroid symptoms like extreme fatigue, significant weight gain, profound cold intolerance, or mental sluggishness that interferes with daily activities. Additionally, consider testing if you have been diagnosed with hypothyroidism but your symptoms have worsened dramatically despite treatment, or if you develop distinctive skin changes that suggest more severe thyroid dysfunction than typical hypothyroidism.
Save a trip to the doctor, go directly to the lab
Instant orders, results often overnight*
Results explained in simple language
Reviewed by US licensed doctors
Fast & confidential, we never sell or share your data
No insurance needed, transparent pricing
What this means
Your TPO antibodies are elevated above the normal range, indicating that your immune system is producing antibodies against your thyroid gland. This is a strong indicator of autoimmune thyroid disease, most commonly Hashimoto's thyroiditis, which can lead to thyroid dysfunction over time and explain symptoms like fatigue, weight changes, or mood issues.
Recommended actions
Consider an anti-inflammatory diet by reducing gluten and processed foods while increasing omega-3 fatty fish
Add selenium-rich foods like Brazil nuts (2-3 per day), eggs, and seafood to help reduce antibody levels
Manage stress through meditation, yoga, or gentle exercise to support immune system balance
Retest in 6-12 months along with TSH and thyroid hormones to monitor progression
Not overhyped or overpriced. Just comprehensive blood testing made simple and for everyone.
3303 reviews
Sample results
Your 24/7 Personal Lab Guide
Quick questions:
