Understanding Lab Tests for Hypogonadism
Written by Private MD Labs Medical Writing Team • Last Updated: September 8, 2025
Hypogonadism is a medical condition where the body's sex glands (testes in men, ovaries in women) produce little or no sex hormones. This condition requires specific hormone blood tests for accurate diagnosis, as symptoms can be subtle and overlap with other health issues.
Top Recommended Test
Testosterone, Total, Male, IA (MALES ONLY)
This test measures total testosterone levels in males. Hypogonadism is characterized by the body's insufficient production of sex hormones, and low testosterone levels are a primary indicator of this condition in men.
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Diagnosing Hypogonadism Through Blood Testing
Blood tests are the primary diagnostic tool for hypogonadism. These tests measure various hormone levels including testosterone, estrogen, and pituitary hormones that regulate sex hormone production. A comprehensive hormone panel helps determine both the presence and type of hypogonadism (primary or secondary).
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Testosterone, Free, Bioavailable and Total, LC/MS/MS
This comprehensive test measures free, bioavailable, and total testosterone using highly accurate LC/MS/MS methodology. Low levels of total testosterone could indicate hypogonadism, a condition in which the body doesn't produce enough sex hormones.
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Follicle-Stimulating Hormone (FSH)
FSH is produced by the pituitary gland and stimulates the production of sex hormones. In men, low levels of FSH can indicate hypogonadism, a condition where the testes do not produce enough testosterone and sperm.
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Luteinizing Hormone (LH)
LH is a pituitary hormone that triggers sex hormone production. Lower levels of LH can result in hypogonadism, a condition causing underproduction of testosterone in men or estrogen in women.
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Estradiol
Estradiol is an important estrogen hormone that also plays a role in male physiology. In males, low levels of estradiol can indicate hypogonadism, a condition characterized by the body's inability to produce enough testosterone.
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Testosterone Total LC/MS/MS
This test uses LC/MS/MS technology for precise testosterone measurement. Hypogonadism is a condition where the body does not produce enough testosterone, which can be detected by low levels of testosterone in the blood.
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Testosterone, Free, LC/MS/MS
Free testosterone represents the bioactive form of testosterone. Hypogonadism is a condition in which the body doesn't produce enough testosterone, and low levels of free testosterone in a lab test can indicate this condition.
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Estradiol, Ultrasensitive, LC/MS/MS
This ultrasensitive test can detect very low levels of estradiol. In males, low levels of estradiol can indicate hypogonadism, a condition where the body doesn't produce enough sex hormones.
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Testosterone, Free and Total, LC/MS/MS
This comprehensive test measures both free and total testosterone using advanced LC/MS/MS methodology. Hypogonadism is a condition where the body doesn't produce enough testosterone, and low total testosterone levels can indicate this condition.
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Dihydrotestosterone, (DHT) LC/MS/MS
DHT is a potent form of testosterone that plays important roles in male development and function. Low levels of DHT can indicate hypogonadism, a condition characterized by the body's lack of sex hormone production.
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Estrogens (Total), Serum
This test measures total estrogen levels. Hypogonadism is a condition in which the body's sex glands produce little or no hormones, and in males, this can lead to a deficiency in estrogen, among other hormones.
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Estrone, LC/MS/MS
Estrone is one of the main estrogen hormones that also affects male physiology. Low levels of estrone in men can indicate hypogonadism, which is characterized by low testosterone levels and can cause symptoms like erectile dysfunction and fatigue.
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Understanding Your Test Results
Hypogonadism diagnosis typically involves multiple hormone measurements to provide a complete picture. Your healthcare provider will interpret results considering your symptoms, age, and overall health status. Treatment options may include hormone replacement therapy when clinically appropriate.
Important Considerations
The information here is for educational purposes only and is not a substitute for professional medical advice. Always consult with a healthcare provider for diagnosis and treatment.
