Understanding Lab Tests for Hypofibrinogenemia
Written by Private MD Labs Medical Writing Team • Last Updated: September 8, 2025
Hypofibrinogenemia is a rare blood disorder characterized by abnormally low levels of fibrinogen, a crucial protein involved in blood clotting. This condition can be inherited (genetic) or acquired due to liver disease, disseminated intravascular coagulation (DIC), or certain cancers. It can lead to abnormal bleeding and impaired blood clotting function.
Top Recommended Test
Fibrinogen Activity
This test uses the Clauss method to measure the functional activity of fibrinogen in the blood. It is specifically designed to detect fibrinogen deficiency and is a primary diagnostic tool for hypofibrinogenemia. This test can identify both inherited genetic disorders and acquired conditions that result in low fibrinogen levels, helping to assess bleeding risk and clotting function.
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Diagnosing Hypofibrinogenemia
Since hypofibrinogenemia involves a deficiency in a specific blood protein, laboratory testing is the primary method for diagnosis. Specialized blood tests that measure fibrinogen levels are essential to confirm the condition and determine its severity, enabling healthcare providers to develop appropriate treatment strategies.
Other Relevant Tests
Fibrinogen Antigen
This test measures the actual amount of fibrinogen protein present in the blood, regardless of its functional activity. It provides complementary information to the activity test and helps distinguish between different types of fibrinogen disorders. This test is particularly useful for identifying hypofibrinogenemia caused by inherited conditions or acquired factors such as liver disease, DIC, or certain cancers.
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Understanding Your Results
Low fibrinogen levels detected through these tests can indicate hypofibrinogenemia, but the underlying cause requires further medical evaluation. Your healthcare provider will interpret the results in the context of your symptoms, medical history, and other laboratory findings to determine whether the condition is inherited or acquired.
Important Considerations
The information here is for educational purposes only and is not a substitute for professional medical advice. Always consult with a healthcare provider for diagnosis and treatment.
