Understanding Lab Tests for Hypersensitivity Pneumonitis
Written by Private MD Labs Medical Writing Team • Last Updated: September 8, 2025
Hypersensitivity pneumonitis, also known as extrinsic allergic alveolitis, is a complex lung condition caused by an immune response to inhaled organic dusts, molds, and other environmental allergens. While the diagnosis relies primarily on imaging studies and clinical evaluation, blood tests are fundamental for identifying the specific allergens triggering the immune response and monitoring the body's reaction to these substances.
Top Recommended Test
Alternaria alternata (m6) IgG
This test measures IgG antibodies against Alternaria alternata, a common environmental fungus. High levels indicate sensitization and potential allergic response to this fungus, which can trigger the immune-mediated lung inflammation characteristic of hypersensitivity pneumonitis.
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The Role of Blood Testing in Hypersensitivity Pneumonitis
Although there isn't a single blood test to diagnose hypersensitivity pneumonitis itself, testing is essential for detecting elevated antibody levels that indicate sensitization to specific environmental allergens. These tests help identify the causative agents and assess the immune system's response, which is crucial for treatment planning and environmental control measures.
Other Relevant Tests
Aureobasidium Pullulans (m12) IgG
This test measures IgG antibodies against Aureobasidium Pullulans, a mold that can trigger hypersensitivity pneumonitis. High levels indicate the body is mounting an immune response to this allergen, which can cause inflammation of the alveoli within the lung.
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Allergen Specific (m11) IgG Rhizopus nigricans
This test detects IgG antibodies to Rhizopus nigricans, a mold that can cause hypersensitivity pneumonitis through immune system activation. Elevated levels could indicate potential for developing this rare lung condition.
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Respiratory Allergy Panel Region III: GA, northern FL, SC
This comprehensive panel tests for multiple respiratory allergens common in the southeastern United States. It can identify sensitization to various molds and allergens that may cause prolonged lung inflammation, cough, shortness of breath, and fatigue associated with hypersensitivity pneumonitis.
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Respiratory Allergy Panel Region IV: FL, south of Orlando
This regional panel tests for allergens specific to southern Florida, including proteins that can trigger hypersensitivity pneumonitis. The panel helps identify immune responses to inhaled substances that cause lung inflammation in this geographic area.
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Respiratory Allergy Profile Region I: CT, MA, ME, NH, NJ, NY, PA, RI, VT
This comprehensive profile tests for respiratory allergens common in the northeastern United States. It can detect sensitization to high concentrations of various allergens including Alternaria alternata, which can lead to lung inflammation and potentially scarring of lung tissue.
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Respiratory Allergy Profile Region VI: AL, AR, LA, MS
This regional profile identifies allergen sensitivities common in the Gulf Coast states. It tests for various molds including Penicillium notatum, which can cause hypersensitivity pneumonitis through prolonged exposure and allergic reactions to inhaled organic particles.
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Allergen Specific IgE Fusarium solani
This test measures IgE antibodies to Fusarium solani, an organic dust component that can trigger extrinsic allergic alveolitis. Elevated IgE levels might suggest an immediate hypersensitivity reaction that could contribute to hypersensitivity pneumonitis development.
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Trichoderma viride (m15) IgG
This test detects IgG antibodies against Trichoderma viride, a mold found in organic dusts. Elevated levels could suggest hypersensitivity pneumonitis, as this antibody response indicates immune system activation against inhaled organic particles that cause inflammation of the lung's airspaces.
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Understanding Your Results
These blood tests help healthcare providers identify which specific allergens may be triggering your immune response and contributing to lung inflammation. The results, combined with clinical symptoms and imaging studies, provide a comprehensive picture for diagnosis and treatment planning. Identifying the causative allergen is essential for implementing effective avoidance strategies.
Important Considerations
The information here is for educational purposes only and is not a substitute for professional medical advice. Always consult with a healthcare provider for diagnosis and treatment.
