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Hyperfibrinogenemia is a condition characterized by elevated levels of fibrinogen, a protein essential for blood clotting. It is caused by inflammation, infections, cancer, pregnancy, or other underlying health conditions that trigger increased fibrinogen production. The Fibrinogen Antigen test is the most important test for diagnosis because it directly measures fibrinogen protein levels in the blood.
Hyperfibrinogenemia is caused by conditions that trigger increased production of fibrinogen in the liver. Acute and chronic inflammation, bacterial or viral infections, cancer (especially lung, stomach, or kidney cancer), pregnancy, and autoimmune diseases like rheumatoid arthritis are primary causes. Tissue damage from surgery, trauma, or burns also stimulates the liver to produce excess fibrinogen as part of the body's healing response. Additionally, conditions like diabetes, obesity, and smoking can contribute to chronically elevated fibrinogen levels.
The Fibrinogen Antigen test is the most important test for hyperfibrinogenemia because it directly measures the amount of fibrinogen protein circulating in your blood. This test provides a precise quantitative measurement that identifies elevated levels above the normal range of 200-400 mg/dL. When fibrinogen levels are elevated, it indicates increased risk for abnormal blood clot formation in veins and arteries. Your healthcare provider may also order additional tests like C-reactive protein (CRP) or complete blood count (CBC) to identify underlying inflammatory conditions causing the elevated fibrinogen.
You should get tested if you have unexplained blood clots, a family history of clotting disorders, or chronic inflammatory conditions like rheumatoid arthritis or inflammatory bowel disease. Testing is also important if you are pregnant and have a history of pregnancy complications, if you have cancer, or if you are being evaluated for cardiovascular disease risk. Additionally, if you have had recurrent miscarriages or stroke at a young age, your doctor may recommend fibrinogen testing to assess your clotting risk and determine if treatment is necessary.
What this means
Your fibrinogen levels are elevated above the optimal range, which may indicate inflammation in your body or increased cardiovascular risk. While mildly elevated levels are common with stress, infection, or lifestyle factors, consistently high fibrinogen can contribute to thicker blood and higher risk of blood clots over time.
Recommended actions
Incorporate regular cardiovascular exercise like brisk walking, swimming, or cycling for 30 minutes most days
Adopt an anti-inflammatory diet rich in omega-3s from fish, nuts, and colorful vegetables
Quit smoking if applicable and manage stress through meditation or yoga
Retest in 3-6 months to monitor trends and effectiveness of lifestyle changes
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