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Hypercalcemia is a condition characterized by abnormally high levels of calcium in the blood. It is caused by overactive parathyroid glands (hyperparathyroidism), certain cancers, excessive vitamin D intake, or specific medications. The Calcium, Serum test is the most important test for diagnosis because it directly measures total calcium levels in the blood.
Hypercalcemia is caused by overactive parathyroid glands (hyperparathyroidism), which release too much parathyroid hormone (PTH) that pulls calcium from bones into the bloodstream. Other causes include certain cancers like lung or breast cancer that release bone-breaking substances, taking too much calcium or vitamin D supplements, prolonged immobilization, thyroid disorders, and medications like lithium or thiazide diuretics. In some cases, rare genetic conditions or chronic kidney disease can also lead to elevated calcium levels.
The Calcium, Serum test is the most important test for hypercalcemia because it directly measures total calcium levels in your blood and confirms whether you have elevated levels. This simple blood test serves as the primary screening tool that doctors use first. For a more detailed evaluation, the Calcium, Ionized, Serum test is essential because it measures the active form of calcium that actually affects your body, giving a more precise picture of your calcium status. Additional tests like the Comprehensive Metabolic Profile help assess how high calcium is affecting your kidneys and overall metabolism, while the Vitamin D, 1,25-Dihydroxy test identifies whether excessive vitamin D is contributing to the problem.
You should get tested if you experience persistent fatigue, excessive thirst and urination, confusion or difficulty concentrating, nausea and vomiting, constipation, bone pain or frequent fractures, or irregular heartbeat. Testing is also important if you have a history of overactive parathyroid glands, cancer, kidney stones, or if you take high doses of calcium or vitamin D supplements. If you have unexplained muscle weakness or notice changes in your mental clarity, these could be signs of elevated calcium that need evaluation.
What this means
Your calcium levels are slightly below the optimal range. While this is not immediately concerning, it may contribute to muscle cramps, weakness, or tingling sensations over time. Low calcium can also affect bone density and increase your risk of osteoporosis if left unaddressed.
Recommended actions
Increase calcium-rich foods like dairy, leafy greens, almonds, and fortified foods
Ensure adequate vitamin D intake through sunlight or supplementation to improve calcium absorption
Consider magnesium-rich foods like pumpkin seeds and spinach, as magnesium supports calcium balance
Retest in 3-6 months after dietary changes to monitor improvement
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