Understanding Lab Tests for HSV-2 Reactivation
Written by Private MD Labs Medical Writing Team • Last Updated: September 8, 2025
HSV-2 reactivation occurs when the herpes simplex virus type 2, which remains dormant in the body after initial infection, becomes active again. While reactivation is often diagnosed based on symptoms like genital lesions, many reactivations can be asymptomatic, making blood testing valuable for detection and monitoring.
Recommended Test
Herpes Simplex Virus 2 (IgG), with Reflex to HSV-2 Inhibition
This specialized test measures HSV-2 IgG antibodies in the blood. Since HSV-2 remains in the body for life after infection, a sudden increase in HSV-2 IgG antibodies can indicate viral reactivation, even when no symptoms are present. The reflex to HSV-2 inhibition provides additional specificity to confirm the presence of HSV-2 antibodies.
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The Role of Blood Testing in HSV-2 Reactivation
Blood tests can help detect HSV-2 reactivation by measuring specific antibodies that the immune system produces in response to viral activity. These tests are particularly useful for identifying asymptomatic reactivations and monitoring the body's immune response to the virus.
Understanding HSV-2 Reactivation
After initial infection, HSV-2 establishes a lifelong presence in the nervous system. Reactivations can be triggered by various factors including stress, illness, immunosuppression, or other conditions that affect the immune system. Many people experience asymptomatic reactivations, making blood testing an important tool for monitoring viral activity.
Important Considerations
The information here is for educational purposes only and is not a substitute for professional medical advice. Always consult with a healthcare provider for diagnosis and treatment of HSV-2 and its reactivations.
