Understanding Lab Tests for HLA B27 Disease
Written by Private MD Labs Medical Writing Team • Last Updated: September 8, 2025
HLA B27 Disease refers to a group of autoimmune and inflammatory disorders strongly associated with the presence of the HLA-B27 gene. These conditions, including ankylosing spondylitis, reactive arthritis, and other spondyloarthropathies, typically involve chronic arthritis and inflammation affecting the spine, joints, and other body systems.
Recommended Test
HLA B Low Resolution
This genetic test identifies the presence of HLA-B27 and other HLA-B alleles in your blood. Since HLA B27 Disease encompasses disorders strongly linked to the HLA-B27 gene, this test is essential for confirming genetic predisposition and supporting the diagnosis of conditions like ankylosing spondylitis, reactive arthritis, and other inflammatory joint diseases associated with this genetic marker.
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Diagnosing HLA B27 Associated Conditions
While clinical symptoms and imaging studies help diagnose specific HLA B27-related conditions, genetic testing for the HLA-B27 marker is a crucial diagnostic tool. This blood test can confirm the presence of the genetic factor that significantly increases the risk of developing these inflammatory disorders.
Understanding Your Results
A positive HLA-B27 test indicates the presence of this genetic marker, which significantly increases the likelihood of developing HLA B27-associated diseases. However, not everyone with HLA-B27 will develop these conditions, and the test results should be interpreted alongside clinical symptoms and other diagnostic findings by a healthcare provider.
Important Considerations
The information here is for educational purposes only and is not a substitute for professional medical advice. Always consult with a healthcare provider for diagnosis and treatment.
