Understanding Lab Tests for Herpes Simplex Virus Type 2 (HSV-2) Infection
Written by Private MD Labs Medical Writing Team • Last Updated: September 8, 2025
Herpes Simplex Virus Type 2 (HSV-2) is a sexually transmitted infection that primarily causes genital herpes. While HSV-2 can sometimes be asymptomatic or cause mild symptoms that go unnoticed, specific blood tests can accurately detect the presence of the virus by measuring antibodies your immune system produces in response to the infection.
Top Recommended Test
Herpes Simplex Virus 1 and 2 (IgG), Type Specific Antibodies (HerpeSelect®)
This comprehensive test detects type-specific IgG antibodies for both HSV-1 and HSV-2, allowing healthcare providers to distinguish between the two types of herpes viruses. The presence of HSV-2 IgG antibodies indicates an infection with Herpes Simplex Virus Type 2, which is usually associated with genital herpes. Positive results typically indicate a current or past infection.
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Why Blood Testing for HSV-2 is Important
Many people with HSV-2 may not experience obvious symptoms or may mistake them for other conditions. Blood testing is essential for confirming an HSV-2 infection, allowing for proper treatment decisions, partner notification, and prevention of transmission. These tests detect IgG antibodies, which indicate either a current or past infection with the virus.
Other Relevant Tests
Herpes Simplex Virus 2 (IgG), with Reflex to HSV-2 Inhibition
This specialized test focuses specifically on HSV-2 and includes a confirmatory inhibition step to ensure accurate results. High levels of HSV-2 IgG antibodies indicate that the person has been infected with the virus that primarily causes genital herpes. This test is particularly useful for confirming an HSV-2 infection with enhanced specificity.
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Understanding Your Test Results
IgG antibodies typically develop 2-12 weeks after initial infection, so testing too soon after potential exposure may result in false negatives. A positive result indicates exposure to HSV-2, while a negative result suggests no infection, provided sufficient time has passed since potential exposure. Your healthcare provider can help interpret results and discuss treatment options if needed.
Important Considerations
The information here is for educational purposes only and is not a substitute for professional medical advice. Always consult with a healthcare provider for diagnosis, treatment, and guidance on preventing transmission to partners.
