Hemorrhagic disease is a group of bleeding disorders caused by defects in blood clotting that lead to excessive or prolonged bleeding. It is caused by deficiencies or dysfunction in clotting factors like fibrinogen, platelets, or other proteins in the coagulation cascade. The Fibrinogen Activity test is the most important test for diagnosis because it measures the functional ability of fibrinogen to form stable blood clots.
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Hemorrhagic disease is caused by defects in the blood clotting process, including deficiencies in clotting factors like fibrinogen, Factor VIII, Factor IX, or von Willebrand factor, as well as platelet disorders. These conditions can be inherited, such as hemophilia A and B, or acquired through liver disease, vitamin K deficiency, or autoimmune disorders that affect clotting proteins. When any component of the coagulation cascade is missing or dysfunctional, your body cannot form stable blood clots, leading to excessive bleeding even from minor injuries.
The Fibrinogen Activity test is the most important test for hemorrhagic disease because it measures how well fibrinogen converts to fibrin to form stable blood clots. This test detects fibrinogen deficiency or dysfunction, which is a common underlying cause of bleeding disorders. Low fibrinogen activity indicates your blood cannot clot properly, helping doctors identify whether your bleeding is due to fibrinogen problems specifically. Additional tests like PT, PTT, and platelet counts may also be ordered to evaluate other parts of the clotting cascade, but fibrinogen activity directly measures the final step in clot formation.
You should get tested if you experience frequent nosebleeds that are hard to stop, easy bruising from minor bumps, bleeding gums during brushing, unusually heavy menstrual periods, or prolonged bleeding after cuts or dental procedures. Getting tested is especially important if you have unexplained bleeding into joints or muscles, a family history of bleeding disorders, or if you are planning surgery and have concerns about excessive bleeding. Early diagnosis helps prevent complications and allows your healthcare provider to develop a treatment plan before serious bleeding episodes occur.
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What this means
Your fibrinogen level is elevated above the optimal range, which indicates increased inflammation in your body and higher cardiovascular risk. Elevated fibrinogen makes your blood more prone to clotting and is associated with increased risk of heart attack and stroke. This is a meaningful finding that warrants attention to reduce inflammation and protect your heart health.
Recommended actions
Adopt an anti-inflammatory diet rich in omega-3 fatty acids from fish, walnuts, and flaxseeds
Engage in regular aerobic exercise like brisk walking, swimming, or cycling for 30 minutes most days
If you smoke, prioritize quitting as smoking significantly elevates fibrinogen levels
Retest in 3-6 months after implementing lifestyle changes to monitor improvement
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