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Hashimoto's thyroiditis is an autoimmune disorder where the immune system attacks the thyroid gland, leading to chronic inflammation and hypothyroidism. It is caused by the production of thyroid peroxidase (TPO) antibodies and thyroglobulin antibodies that target thyroid proteins and damage the gland. The Thyroid Peroxidase (TPO) and Thyroglobulin Antibodies test is the most important test for diagnosing Hashimoto's thyroiditis because it detects both primary autoimmune markers.
Hashimoto's thyroiditis is caused by an autoimmune reaction where your immune system produces antibodies that attack the thyroid gland. Specifically, thyroid peroxidase (TPO) antibodies and thyroglobulin antibodies target thyroid proteins, causing chronic inflammation and progressive damage to the gland. This autoimmune attack gradually destroys thyroid tissue, reducing the gland's ability to produce essential thyroid hormones like T3 and T4, ultimately leading to hypothyroidism.
The Thyroid Peroxidase (TPO) and Thyroglobulin Antibodies test is the most important test for Hashimoto's thyroiditis because it detects both primary autoimmune markers in a single panel. TPO antibodies are present in about 90% of people with Hashimoto's and indicate that your immune system is attacking the enzyme responsible for thyroid hormone production. Thyroglobulin antibodies provide additional confirmation of the autoimmune attack on thyroid proteins. Together, elevated levels of these antibodies definitively confirm the autoimmune nature of the condition and distinguish Hashimoto's from other causes of thyroid dysfunction.
You should get tested if you experience persistent fatigue, unexplained weight gain, cold intolerance, dry skin, hair loss, or depression. Testing is especially important if you have a family history of thyroid disease or other autoimmune conditions, if you are a woman of childbearing age planning pregnancy, or if you notice a visible swelling in your neck (goiter). Early detection through antibody testing helps prevent complications and allows for timely treatment before significant thyroid damage occurs.
What this means
Your TPO antibodies are elevated above the normal range, indicating that your immune system is producing antibodies against your thyroid gland. This is a strong indicator of autoimmune thyroid disease, most commonly Hashimoto's thyroiditis, which can lead to thyroid dysfunction over time and explain symptoms like fatigue, weight changes, or mood issues.
Recommended actions
Consider an anti-inflammatory diet by reducing gluten and processed foods while increasing omega-3 fatty fish
Add selenium-rich foods like Brazil nuts (2-3 per day), eggs, and seafood to help reduce antibody levels
Manage stress through meditation, yoga, or gentle exercise to support immune system balance
Retest in 6-12 months along with TSH and thyroid hormones to monitor progression
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