Hantavirus Pulmonary Syndrome is a rare but severe respiratory disease that can progress to life-threatening lung failure. It is caused by hantavirus infection transmitted through inhalation of airborne particles from infected rodent droppings, urine, or saliva, particularly from deer mice in North America. The Respiratory Allergy Profile is the most important test for distinguishing allergic reactions to rodent proteins from viral hantavirus infection, as both involve similar environmental exposures.
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Hantavirus Pulmonary Syndrome is caused by hantavirus infection, primarily transmitted when you breathe in air contaminated with the virus from rodent droppings, urine, or saliva. The Sin Nombre virus, carried by deer mice, is the most common cause in the United States. Infection typically occurs when cleaning barns, sheds, or other enclosed spaces where rodents have been active, or when disturbing rodent nests. Direct contact with rodents or their waste can also transmit the virus, though this is less common than airborne transmission.
The Respiratory Allergy Profile Region XVII is the most important blood test for people with suspected hantavirus exposure because it helps differentiate between allergic reactions to rodent proteins and actual viral infection. This comprehensive panel detects immune responses to mouse urine proteins and other environmental allergens common in rodent-infested areas. While hantavirus infection itself requires specialized viral antibody testing and clinical evaluation at medical facilities, this allergy profile provides critical information about whether your respiratory symptoms might be related to allergic responses rather than viral infection. This distinction is essential because both conditions involve similar environmental exposures but require completely different treatment approaches.
You should get tested if you develop fever, muscle aches, and shortness of breath within 1-8 weeks after exposure to rodents or their droppings, especially in rural or wilderness areas. Get immediate medical attention if you experience difficulty breathing, cough, or chest tightness after cleaning spaces where rodents have been active. Early symptoms can resemble the flu but rapidly progress to severe respiratory distress. If you work in environments with rodent exposure like barns, warehouses, or vacation cabins, testing becomes especially important when respiratory symptoms develop.
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What this means
Your total IgE level is elevated, which indicates your immune system is producing higher amounts of allergy antibodies. This is common in people with environmental allergies and suggests you're sensitized to one or more allergens tested in this panel. Elevated IgE supports that your respiratory symptoms are allergy-related rather than other causes.
Recommended actions
Review your specific allergen results to identify which triggers to avoid
Use HEPA air filters and keep windows closed during high pollen seasons
Consider discussing immunotherapy with your doctor if multiple allergens are positive
Retest annually if undergoing treatment to monitor your immune response
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