Understanding Lab Tests for Fibrinogen Deficiency (Hypofibrinogenemia or Afibrinogenemia)
Written by Private MD Labs Medical Writing Team • Last Updated: September 8, 2025
Fibrinogen deficiency encompasses rare genetic bleeding disorders where the body produces insufficient fibrinogen (hypofibrinogenemia) or no fibrinogen at all (afibrinogenemia). Fibrinogen is a crucial protein involved in blood clotting, and deficiencies can lead to serious bleeding complications.
Recommended Test
Fibrinogen Activity
This test directly measures the functional activity of fibrinogen in the blood. Since fibrinogen deficiency disorders result from the body producing too little or no fibrinogen, low levels of fibrinogen activity will clearly indicate these conditions. This is the primary diagnostic test for confirming hypofibrinogenemia or afibrinogenemia.
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Diagnosing Fibrinogen Deficiency
Since fibrinogen deficiency symptoms can overlap with other bleeding disorders, accurate diagnosis requires specific laboratory testing that measures fibrinogen levels and activity in the blood. Early diagnosis is essential for proper management and preventing bleeding complications.
Understanding Your Results
Normal fibrinogen activity levels typically range from 200-400 mg/dL. In hypofibrinogenemia, levels are reduced but detectable, while in afibrinogenemia, fibrinogen is virtually absent. Your healthcare provider will interpret these results in the context of your symptoms and medical history.
Important Considerations
The information here is for educational purposes only and is not a substitute for professional medical advice. Always consult with a healthcare provider for diagnosis and treatment of bleeding disorders.
