Understanding Lab Tests for Eosinophilic Esophagitis (EoE)

Written by Private MD Labs Medical Writing Team • Last Updated: September 8, 2025

Eosinophilic Esophagitis (EoE) is a chronic immune system disease where eosinophils (a type of white blood cell) accumulate in the esophagus, causing inflammation and difficulty swallowing. While EoE is primarily diagnosed through endoscopy and tissue biopsy, blood testing plays a fundamental role in identifying potential food triggers and supporting overall management.

Recommended Test

Lemon (f208) IgG

This test measures IgG antibodies specific to lemon proteins in the blood. Since EoE is a chronic immune system disease where eosinophils build up in the esophagus as a reaction to foods and allergens, elevated levels of Lemon IgG antibodies could indicate a food sensitivity that may be triggering the inflammatory response characteristic of EoE.

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The Role of Blood Testing in EoE Management

There is no single blood test that can diagnose EoE itself. However, lab testing is essential for identifying food sensitivities and allergies that may trigger the inflammatory response in the esophagus. Since EoE often develops as a reaction to specific foods, allergens, or acid reflux, identifying these triggers through blood work is crucial for developing an effective treatment plan.

Understanding Your Results

Food allergy and sensitivity testing helps identify potential dietary triggers that may be contributing to esophageal inflammation. By identifying and eliminating trigger foods from the diet, many people with EoE experience significant improvement in symptoms. Testing for multiple food allergens is often recommended as part of a comprehensive approach to EoE management.

Important Considerations

The information here is for educational purposes only and is not a substitute for professional medical advice. Always consult with a healthcare provider for diagnosis and treatment. EoE diagnosis typically requires endoscopy and tissue biopsy, and blood tests serve as supportive tools in management.

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