Understanding Lab Tests for Ectopic ACTH Syndrome
Written by Private MD Labs Medical Writing Team • Last Updated: September 8, 2025
Ectopic ACTH syndrome is a rare condition where tumors outside the pituitary gland produce adrenocorticotropic hormone (ACTH). This abnormal ACTH production leads to excessive cortisol levels, causing symptoms similar to Cushing's syndrome. Blood testing is essential for diagnosing this condition and distinguishing it from other causes of elevated cortisol.
Recommended Test
Adrenocorticotropic Hormone (ACTH)
This test directly measures ACTH levels in the blood, which is the primary diagnostic marker for ectopic ACTH syndrome. When non-pituitary tumors produce ACTH, blood levels become abnormally elevated, leading to excessive stimulation of the adrenal glands and overproduction of cortisol. High ACTH levels combined with elevated cortisol help confirm the diagnosis and guide further treatment decisions.
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Diagnosing Ectopic ACTH Syndrome
The diagnosis of ectopic ACTH syndrome requires specific hormone testing to confirm abnormal ACTH production from non-pituitary sources. This testing helps healthcare providers differentiate between pituitary-dependent and ectopic sources of ACTH, which is crucial for determining the appropriate treatment approach.
Understanding Your Results
In ectopic ACTH syndrome, ACTH levels are typically significantly elevated compared to normal ranges. Your healthcare provider will interpret these results alongside other clinical findings and may recommend additional testing or imaging studies to locate the source of ectopic ACTH production.
Important Considerations
The information here is for educational purposes only and is not a substitute for professional medical advice. Always consult with a healthcare provider for diagnosis and treatment of ectopic ACTH syndrome or any related symptoms.
