Understanding Lab Tests for Drug rash with eosinophilia and systemic symptoms (DRESS)
Written by Private MD Labs Medical Writing Team • Last Updated: September 8, 2025
Drug rash with eosinophilia and systemic symptoms (DRESS) is a severe, potentially life-threatening drug reaction characterized by widespread skin rash, fever, elevated white blood cells called eosinophils, and damage to internal organs such as the liver, kidneys, and heart. DRESS syndrome is primarily diagnosed through clinical symptoms and medical history, but specialized blood tests can help identify severe drug reactions and monitor the condition.
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This specialized test can detect severe drug reactions by measuring specific biomarkers. In rare cases, elevated levels of this biomarker can indicate DRESS syndrome, a severe drug reaction that causes skin rash, fever, and damage to internal organs including the liver and kidneys. This testing helps identify penicillin-related reactions that may contribute to DRESS development.
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Why Blood Testing is Important for DRESS
While DRESS syndrome is diagnosed based on clinical presentation and symptom patterns, blood tests are fundamental for detecting drug-specific reactions, monitoring organ function, and assessing the severity of the immune system response. Testing can help identify which medications may be causing the reaction and guide treatment decisions.
Understanding DRESS Syndrome
DRESS typically develops 2-8 weeks after starting a new medication and can affect multiple organ systems. Common triggering medications include certain antibiotics, anticonvulsants, and other prescription drugs. Early recognition and discontinuation of the causative medication is crucial for recovery and preventing serious complications.
Important Considerations
The information here is for educational purposes only and is not a substitute for professional medical advice. DRESS syndrome is a medical emergency requiring immediate healthcare attention. Always consult with a healthcare provider for diagnosis and treatment.
